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Yahui Li
Researcher at North Carolina Central University
Publications - 8
Citations - 38
Yahui Li is an academic researcher from North Carolina Central University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 3 publications receiving 8 citations.
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Book ChapterDOI
NOTCH and Esophageal Squamous Cell Carcinoma
TL;DR: This chapter summarizes the current understanding of the NOTCH pathway in normal esophagus and in ESCC and suggests that further studies are warranted to develop NOTCH activators for the prevention of ES CC and NOTCH inhibitors for targeted therapy of a subset of ESCC with activated NotCH pathway.
Journal ArticleDOI
Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells.
Menghan Shi,Menghan Shi,Shuang Ren,Shuang Ren,Hao Chen,Jing Li,Caizhi Huang,Yahui Li,Yuning Han,Yong Li,Zheng Sun,Xiaoxin Chen,Xiaoxin Chen,Zhaohui Xiong +13 more
TL;DR: The data support a novel mechanism of alcohol‐induced esophageal injury through the inhibition of NOTCH–PAX9 signaling and thus suppressed PAX9 expression in esophagal squamous epithelial cells in vitro and in vivo.
Journal ArticleDOI
Development of targeted therapy of NRF2high esophageal squamous cell carcinoma.
Chorlada Paiboonrungruang,Emily Simpson,Zhaohui Xiong,Caizhi Huang,Jianying Li,Yahui Li,Xiaoxin Chen,Xiaoxin Chen +7 more
TL;DR: In this article, a review of NRF2 inhibitors and their mechanisms of action, screening novel drug targets, and evaluation of the NRF 2 activity in the esophagus is presented.
Journal ArticleDOI
PAX9 in Cancer Development
Xiaoxin Chen,Yahui Li,Chorlada Paiboonrungruang,Yong Li,Heiko Peters,Ralf Kist,Zhaohui Xiong +6 more
TL;DR: In summary, extensive studies on PAX9 in its cellular and tissue contexts are warranted in various cancers, in particular, HNSCC, ESCC, lung cancer, and cervical SCC.
Posted ContentDOI
Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia
Chorlada Paiboonrungruang,Zhaohui Xiong,David R. Lamson,Yahui Li,Brittany M. Bowman,Julius Chembo,Caizhi Huang,Jianying Li,Eric W. Livingston,Jonathan E. Frank,Vivian Chen,Yong Li,Bernard E. Weissman,Hong Yuan,Kevin P. Williams,Marian Major,Xiaoxin Chen +16 more
TL;DR: Pyrimethamine and mitoxantrone were shown to suppress NRF2 and NQO1 expression in human esophageal squamous cell carcinoma (ESCC) cells in both dose and time-dependent manners as discussed by the authors .