NOTCH and Esophageal Squamous Cell Carcinoma
TLDR
This chapter summarizes the current understanding of the NOTCH pathway in normal esophagus and in ESCC and suggests that further studies are warranted to develop NOTCH activators for the prevention of ES CC and NOTCH inhibitors for targeted therapy of a subset of ESCC with activated NotCH pathway.Abstract:
Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research on its mechanisms, prevention, and therapy. Recent studies have shown that NOTCH mutations are commonly seen in human ESCC. This chapter summarizes our current understanding of the NOTCH pathway in normal esophagus and in ESCC. In normal esophagus, NOTCH pathway regulates the development of esophageal squamous epithelium, in particular, squamous differentiation. Exposure to extrinsic and intrinsic factors, such as gastroesophageal reflux, alcohol drinking, and inflammation, downregulates the NOTCH pathway and thus inhibits squamous differentiation of esophageal squamous epithelial cells. In ESCC, NOTCH plays a dual role as both a tumor suppressor pathway and an oncogenic pathway. In summary, further studies are warranted to develop NOTCH activators for the prevention of ESCC and NOTCH inhibitors for targeted therapy of a subset of ESCC with activated NOTCH pathway.read more
Citations
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Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
TL;DR: An independent approach based solely on cancer genome sequencing and epidemiological data suggested that R mutations are responsible for two-thirds of the mutations in human cancers, and results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment.
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METTL3-mediated m6A mRNA modification promotes esophageal cancer initiation and progression via Notch signaling pathway.
Hui Han,Chunlong Yang,Shuishen Zhang,Maosheng Cheng,Siyao Guo,Yan Zhu,Jieyi Ma,Yu Liang,Lu Wang,Siyi Zheng,Zhaoyu Wang,Demeng Chen,Yi-Zhou Jiang,Shuibin Lin +13 more
TL;DR: In this paper, the N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3) was found to be significantly upregulated in esophageal squamous cell carcinoma (ESCC) and associated with poor patient prognosis.
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Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy
TL;DR: In this article , the authors comprehensively analyzed the genomic alterations in EAC and ESCC and summarized the potential role of the genetic alterations in the development of esophageal cancer.
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Comparative genomic analysis of esophageal squamous cell carcinoma and adenocarcinoma: New opportunities towards molecularly targeted therapy
TL;DR: This review comprehensively analyze the genomic alterations in EAC and ESCC and summarizes the potential role of the genetic alterations in the development of esophageal cancer.
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Comprehensive Analysis of the Expression of TGF-β Signaling Regulators and Prognosis in Human Esophageal Cancer.
TL;DR: In this paper, the authors used a variety of bioinformatics methods to analyze the expression and survival data of TGF-β signal regulators in patients with esophageal cancer.
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