Y
Yan Chen
Researcher at Hunan University
Publications - 55
Citations - 5551
Yan Chen is an academic researcher from Hunan University. The author has contributed to research in topics: Aptamer & Chemistry. The author has an hindex of 35, co-authored 48 publications receiving 5067 citations. Previous affiliations of Yan Chen include Northeast Forestry University & University of Florida.
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Journal ArticleDOI
Search for low-mass weakly interacting massive particles with SuperCDMS.
R. Agnese,Adam Anderson,M. Asai,D. Balakishiyeva,R. Basu Thakur,D. A. Bauer,J. Beaty,J. Billard,A. W. Borgland,M. A. Bowles,D. Brandt,P. L. Brink,R. Bunker,Blas Cabrera,David O. Caldwell,David G. Cerdeño,H. Chagani,Yan Chen,M. Cherry,Jodi Cooley,B. Cornell,C. H. Crewdson,P. Cushman,Miguel Daal,D. Devaney,P. Di Stefano,E. Do Couto E Silva,T. Doughty,L. Esteban,S. Fallows,Enectali Figueroa-Feliciano,G. Godfrey,Sunil Golwala,J. Hall,Sissel Hansen,H. R. Harris,S. A. Hertel,B. A. Hines,T. Hofer,Donald J. Holmgren,L. Hsu,Martin E. Huber,A. Jastram,O. Kamaev,B. Kara,M. H. Kelsey,S. Kenany,A. Kennedy,M. Kiveni,K. Koch,A. Leder,B. Loer,E. Lopez Asamar,R. Mahapatra,Vuk Mandic,Cristián Martínez,Kevin A. McCarthy,N. Mirabolfathi,Robert A. Moffatt,R. H. Nelson,L. Novak,K. L. Page,R. Partridge,M. Pepin,A. Phipps,M. Platt,K. Prasad,Matt Pyle,H. Qiu,W. Rau,P. Redl,A. Reisetter,R. Resch,Y. Ricci,M. Ruschman,Tarek Saab,Bernard Sadoulet,J. Sander,R. Schmitt,K. Schneck,R. W. Schnee,S. Scorza,D. N. Seitz,B. Serfass,B. Shank,Danielle Speller,Astrid Tomada,S. Upadhyayula,A. N. Villano,B. Welliver,Douglas Wright,S. J. Yellin,J. J. Yen,Betty A. Young,J. Zhang +94 more
TL;DR: The first search for weakly interacting massive particles (WIMPs) using the background rejection capabilities of SuperCDMS was reported in this article, where an exposure of 577 kg days was analyzed for WIMPs with mass <30 ǫ, with the signal region blinded.
Journal ArticleDOI
Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization.
Ronghua Yang,Jianyu Jin,Yan Chen,Na Shao,Huaizhi Kang,Zeyu Xiao,Zhiwen Tang,Yanrong Wu,Zhi Zhu,Weihong Tan +9 more
TL;DR: An effective, novel self-assembled single-wall carbon nanotube (SWNT) complex with an oligonucleotide is reported and its feasibility in recognizing and detecting specific DNA sequences in a single step in a homogeneous solution is demonstrated.
Journal ArticleDOI
Pyrene-excimer probes based on the hybridization chain reaction for the detection of nucleic acids in complex biological fluids.
Jin Huang,Yanrong Wu,Yan Chen,Yan Chen,Yan Chen,Zhi Zhu,Xiaohai Yang,Chaoyong James Yang,Kemin Wang,Weihong Tan,Weihong Tan +10 more
TL;DR: China Scholarship Council (CSC); ACS; US NIH; China NSFC; National Basic Research Program of China[2007CB935603, 2010CB732402]; China National Grand Program on Key Infectious Disease[2009ZX10004-312]; Key Project of Natural Science Foundation of China [90606003]; International Science & Technology Cooperation Program ofChina[2010DFB30300].
Journal ArticleDOI
Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells.
Yu-Fen Huang,Dihua Shangguan,Haipeng Liu,Joseph A. Phillips,Xiaoling Zhang,Xiaoling Zhang,Yan Chen,Weihong Tan +7 more
TL;DR: The covalent conjugation of drug and aptamer creates alternative opportunities for targeted therapy, as multiple yet specific aptamers can be “generated” relatively easily by cell‐SELEX for any target cells; this demonstrates the full potential of cell‐ SELEX as a molecular discovery tool for biomedical studies and drug development.
Journal ArticleDOI
Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy.
Jian Wang,Guizhi Zhu,Guizhi Zhu,Mingxu You,Erqun Song,Erqun Song,Mohammed Ibrahim Shukoor,Kejing Zhang,Meghan O. Altman,Yan Chen,Yan Chen,Zhi Zhu,Zhi Zhu,Cheng Zhi Huang,Weihong Tan,Weihong Tan +15 more
TL;DR: This multimodal AuNR-ASP-Ce6 conjugate offers a remarkably improved and synergistic therapeutic effect compared to PTT or PDT alone, providing high specificity and therapeutic efficiency, which can be generalized to other types of cancer therapies.