M
Mingxu You
Researcher at University of Massachusetts Amherst
Publications - 97
Citations - 5887
Mingxu You is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Aptamer & RNA. The author has an hindex of 39, co-authored 84 publications receiving 4862 citations. Previous affiliations of Mingxu You include Hunan University & Southwest University.
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Nanotechnology in plant disease management: DNA-directed silver nanoparticles on graphene oxide as an antibacterial against Xanthomonas perforans.
Ismail Ocsoy,Mathews L. Paret,Muserref Arslan Ocsoy,Sanju Kunwar,Tao Chen,Tao Chen,Mingxu You,Mingxu You,Weihong Tan,Weihong Tan +9 more
TL;DR: Application of Ag@dsDNA@GO at 100 ppm on tomato transplants in a greenhouse experiment significantly reduced the severity of bacterial spot disease compared to untreated plants, giving results similar to those of the current grower standard treatment, with no phytotoxicity.
Journal ArticleDOI
Assembly of aptamer switch probes and photosensitizer on gold nanorods for targeted photothermal and photodynamic cancer therapy.
Jian Wang,Guizhi Zhu,Guizhi Zhu,Mingxu You,Erqun Song,Erqun Song,Mohammed Ibrahim Shukoor,Kejing Zhang,Meghan O. Altman,Yan Chen,Yan Chen,Zhi Zhu,Zhi Zhu,Cheng Zhi Huang,Weihong Tan,Weihong Tan +15 more
TL;DR: This multimodal AuNR-ASP-Ce6 conjugate offers a remarkably improved and synergistic therapeutic effect compared to PTT or PDT alone, providing high specificity and therapeutic efficiency, which can be generalized to other types of cancer therapies.
Journal ArticleDOI
Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy.
Cuichen Wu,Da Han,Tao Chen,Lu Peng,Guizhi Zhu,Mingxu You,Liping Qiu,Kwame Sefah,Xiaobing Zhang,Weihong Tan,Weihong Tan +10 more
TL;DR: A multifunctional aptamer-based DNA nanoassembly structure able to take advantage of facile modular design and assembly, high programmability, excellent biostability and biocompatibility, as well as selective recognition and transportation shows promise as candidates for targeted drug delivery and cancer therapy.
Journal ArticleDOI
Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy
Mingxu You,Guizhi Zhu,Guizhi Zhu,Tao Chen,Tao Chen,Michael J. Donovan,Weihong Tan,Weihong Tan +7 more
TL;DR: A general approach for assembling modular logic gates to execute programmable and higher-order profiling of multiple coexisting cell-surface markers, including several found on cancer cells, with the capacity to report a diagnostic signal and/or deliver targeted photodynamic therapy is reported.
Journal ArticleDOI
A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy
Liping Qiu,Tao Chen,Tao Chen,Ismail Ocsoy,Emir Yasun,Cuichen Wu,Guizhi Zhu,Guizhi Zhu,Mingxu You,Mingxu You,Da Han,Jian-Hui Jiang,Ru-Qin Yu,Weihong Tan,Weihong Tan +14 more
TL;DR: This work has used DNA self-assembly to develop a nuclear-uptake nanodrug system carried by a cell-targeted near-infrared (NIR)-responsive nanotruck for drug-resistant cancer therapy that can efficiently accumulated in the nuclei to effectively kill the cancer cells.