Yan Han

TL;DR: It is reported that intracellular proteotoxic stress reduces global protein synthesis by halting ribosomes on transcripts during elongation, suggesting a dual role of molecular chaperones in facilitating polypeptide elongation and cotranslational folding.

TL;DR: It is shown that colorectal cancer cells undergo metabolic reprogramming after they metastasize and colonize the liver, a key metabolic organ, and upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation.

TL;DR: This work uses an engineered multidomain fusion protein to demonstrate an efficient cotranslational folding immediately after the emergence of the full domain sequence, and provides direct evidence of domain-wise global folding that occurs cOTranslationally in mammalian cells.

TL;DR: It is proposed that the post-initiation pausing of ribosomes represents an inherent signature of the translation machinery to ensure productive translation.

TL;DR: The SENP3-IQGAP2 de-SUMOylation axis is a host defense mechanism of hepatocytes that restores host protein translation and suppresses HBV gene expression.