Yan Peng Xu

TL;DR: A single serine-to-asparagine substitution in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs) and led to more severe microcephaly in the mouse fetus, as well as higher mortality rates in neonatal mice.

TL;DR: In this article, the authors demonstrate that SARS-CoV-2 genomic RNA, as well as the negative-sense RNA, is dynamically N6-methyladenosine (m6A)-modified in human and monkey cells.

TL;DR: This study revealed that the specific DRs are involved in the production of specific sfRNAs in both mammalian and mosquito cells and proposed that DRs functions like a bracket holding the Xrn1-xrRNA complex for sfRNA formation.

TL;DR: Wang et al. as discussed by the authors used a serial passaging of a SARS-CoV-2 clinical isolate in Vero cells to generate a live-attenuated vaccine candidate against COVID-19.

TL;DR: This study describes unique viral and host m6A profiles in contemporary ZIKV‐infected Huh7 cells, highlighting the complexity and importance of m 6A modification during viral infection.