Yan-yan Guo

TL;DR: Findings provide direct evidence that fast neuroprotection by estradiol is partially mediated by GPR30 and the subsequent downregulation of NR2B-containing NMDARs and the modulation of DAPK1 activity by G PR30 may be an important mediator of estradio-dependent neuroprotection.

TL;DR: It is found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed changes in synaptic plasticity, which were associated with a long-term increase in the amount of synaptic N-methyl-d-aspartate receptors, but not that of extrasynaptic NMDARs.

TL;DR: Findings provide direct evidence that alterations of CXCL12 in BLA play critical roles in the development of anxiety induced by systemic inflammation and that CXCR4 may be a potential therapeutic target for inflammation-induced anxiety.

TL;DR: The results suggest that the expression of AMPARs is enhanced in the insular cortex after nerve injury by a pathway involving AC1, AKAP79/150, and PKA, and such enhancement may at least in part contribute to behavioral sensitization together with other cortical regions, such as the anterior cingulate and the prefrontal cortices.

TL;DR: A key role of GPR30 is revealed in neuroprotection via the regulation of astrocyte autophagy andAstrocytic G PR30 is supported as a potential drug target against ischemic brain damage.