Y
Yan Zhao
Researcher at Peking Union Medical College
Publications - 42
Citations - 2059
Yan Zhao is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Influenza A virus. The author has an hindex of 18, co-authored 32 publications receiving 1599 citations. Previous affiliations of Yan Zhao include Shandong Normal University & Capital Medical University.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zhen Zou,Yiwu Yan,Yuelong Shu,Rongbao Gao,Yang Sun,Xiao Li,Xiangwu Ju,Zhu Liang,Qiang Liu,Yan Zhao,Feng Guo,Tian Bai,Zongsheng Han,Jindong Zhu,Huandi Zhou,Fengming Huang,Chang Li,Huijun Lu,Ning Li,Dangsheng Li,Ningyi Jin,Josef M. Penninger,Chengyu Jiang +22 more
TL;DR: It is shown that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II, which appears to be linked to the severity and lethality of infection, at least in some patients.
Journal ArticleDOI
Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells
TL;DR: Results indicate that the cytoxicity of CuO NPs may involve the autophagic pathway in A549 cells, and the use of the Autophagy inhibitors wortmannin and 3-methyladenin significantly improved cell survival.
Journal ArticleDOI
IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus
Chenggang Li,Penghui Yang,Yang Sun,Taisheng Li,Chen Wang,Zhong Wang,Zhen Zou,Yiwu Yan,Wei Wang,Zhongwei Chen,Li Xing,Chong Tang,Xiangwu Ju,Feng Guo,Jiejie Deng,Yan Zhao,Peng Yang,Jun Tang,Huan-ling Wang,Zhongpeng Zhao,Zhinan Yin,Bin Cao,Xiliang Wang,Chengyu Jiang +23 more
TL;DR: It is suggested that IL- 17 plays an important role in S-OIV-induced acute lung injury and that monoclonal antibodies against IL-17 could be useful as a potential therapeutic remedy for future S- OIV H1N1 pandemics.
Journal ArticleDOI
Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection
Yang Sun,Chenggang Li,Yuelong Shu,Xiangwu Ju,Zhen Zou,Hongliang Wang,Shuan Rao,Feng Guo,Haolin Liu,Wenlong Nan,Yan Zhao,Yiwu Yan,Jun Tang,Chen Zhao,Peng Yang,Kangtai Liu,Shunxin Wang,Huijun Lu,Xiao Li,Lei Tan,Rongbao Gao,Jingdong Song,Xiang Gao,Xinlun Tian,Yingzhi Qin,Kai-Feng Xu,Dangsheng Li,Ningyi Jin,Chengyu Jiang +28 more
TL;DR: It is concluded that the autophagic cell death of alveolar epithelial cells likely plays a crucial role in the high mortality rate of H5N1 infection, and it is suggested that autophagy-blocking agents might be useful as prophylactics and therapeutics against infection of humans by the H 5N1 virus.
Journal ArticleDOI
Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients
Fengming Huang,Jing Guo,Zhen Zou,Jun Liu,Bin Cao,Shuyang Zhang,Hui Li,Wei Wang,Miaomiao Sheng,Song Liu,Jingcao Pan,Changjun Bao,Mei Zeng,Haixia Xiao,Guirong Qian,Xinjun Hu,Yuanting Chen,Yu Chen,Yan Zhao,Qiang Liu,Huandi Zhou,Jindong Zhu,Hainv Gao,Shigui Yang,Xiaoli Liu,Shufa Zheng,Jiezuan Yang,Hongyan Diao,Hongcui Cao,Ying Wu,Min Zhao,Shuguang Tan,Dan Guo,Xiliang Zhao,Yicong Ye,Wei Wu,Yingchun Xu,Josef M. Penninger,Dangsheng Li,George F. Gao,Chengyu Jiang,Lanjuan Li +41 more
TL;DR: Findings indicate that angiotensin II is a biomarker for lethality in flu infections, higher than that of C-reactive protein and some clinical parameters such as the PaO2/FiO2 ratio (partial pressure of arterial oxygen to the fraction of inspired oxygen).