Y
Yang Sun
Researcher at Harvard University
Publications - 50
Citations - 3663
Yang Sun is an academic researcher from Harvard University. The author has contributed to research in topics: Lymphangioleiomyomatosis & Lung injury. The author has an hindex of 21, co-authored 44 publications receiving 3109 citations. Previous affiliations of Yang Sun include Peking Union Medical College & University of Cincinnati Academic Health Center.
Papers
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Journal ArticleDOI
Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Yumiko Imai,Keiji Kuba,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria A. Ermolaeva,Maria A. Ermolaeva,Ruud A. W. Veldhuizen,Y.H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John M. Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger +27 more
TL;DR: It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI.
Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zhen Zou,Yiwu Yan,Yuelong Shu,Rongbao Gao,Yang Sun,Xiao Li,Xiangwu Ju,Zhu Liang,Qiang Liu,Yan Zhao,Feng Guo,Tian Bai,Zongsheng Han,Jindong Zhu,Huandi Zhou,Fengming Huang,Chang Li,Huijun Lu,Ning Li,Dangsheng Li,Ningyi Jin,Josef M. Penninger,Chengyu Jiang +22 more
TL;DR: It is shown that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II, which appears to be linked to the severity and lethality of infection, at least in some patients.
Journal ArticleDOI
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model
Yiwu Yan,Zhen Zou,Yang Sun,Xiao Li,Kai-Feng Xu,Yuquan Wei,Ningyi Jin,Chengyu Jiang,Chengyu Jiang +8 more
TL;DR: Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
Journal ArticleDOI
PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.
Chenggang Li,Haolin Liu,Yang Sun,Hongliang Wang,Feng Guo,Shuan Rao,Jiejie Deng,Yanli Zhang,Yufa Miao,Chenying Guo,Jie Meng,Xiping Chen,Limin Li,Dangsheng Li,Haiyan Xu,Heng Wang,Bo Li,Chengyu Jiang +17 more
TL;DR: This report shows that cationic Starburst polyamidoamine dendrimer (PAMAM), a class of nanomaterials that are being widely developed for clinical applications can induce acute lung injury in vivo, and suggests potential remedies to address the growing concerns of nanotechnology safety.
Journal ArticleDOI
A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.
Haolin Liu,Yushi Zhang,Ning Yang,Yanqiong Zhang,Xiaojia Liu,Chenggang Li,Yupei Zhao,Yongyan Wang,Guochao Zhang,Peng Yang,Feng Guo,Yang Sun,Chuanlu Jiang +12 more
TL;DR: Inhibition of autophagy significantly reduced COOH-CNT-induced autophagic cell death and ameliorated acute lung injury in mice, suggesting a potential remedy to address the growing concerns on the safety of nanomaterials.