K
Kai-Feng Xu
Researcher at Peking Union Medical College Hospital
Publications - 97
Citations - 1681
Kai-Feng Xu is an academic researcher from Peking Union Medical College Hospital. The author has contributed to research in topics: Lymphangioleiomyomatosis & Medicine. The author has an hindex of 17, co-authored 83 publications receiving 1284 citations. Previous affiliations of Kai-Feng Xu include Peking Union Medical College.
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Journal ArticleDOI
Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model
Yiwu Yan,Zhen Zou,Yang Sun,Xiao Li,Kai-Feng Xu,Yuquan Wei,Ningyi Jin,Chengyu Jiang,Chengyu Jiang +8 more
TL;DR: Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model.
Journal ArticleDOI
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
Jianhui Ma,Yan Meng,David J. Kwiatkowski,Xinxin Chen,Haiyong Peng,Qian Sun,Xiaojun Zha,Fang Wang,Ying Wang,Yanling Jing,Shu Zhang,Rongrong Chen,Lianmei Wang,Erxi Wu,Guifang Cai,Izabela Malinowska-Kolodziej,Qi Liao,Yuqin Liu,Yi Zhao,Qiang Sun,Kai-Feng Xu,Jianwu Dai,Jiahuai Han,Lizi Wu,Robert Chunhua Zhao,Huangxuan Shen,Hongbing Zhang +26 more
TL;DR: P perturbation of cell differentiation by augmented Notch signaling might be responsible for the underdifferentiated phenotype displayed by certain tumors with an aberrantly activated RTK/PI3K/AKT/mTOR pathway.
Journal ArticleDOI
Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection
Yang Sun,Chenggang Li,Yuelong Shu,Xiangwu Ju,Zhen Zou,Hongliang Wang,Shuan Rao,Feng Guo,Haolin Liu,Wenlong Nan,Yan Zhao,Yiwu Yan,Jun Tang,Chen Zhao,Peng Yang,Kangtai Liu,Shunxin Wang,Huijun Lu,Xiao Li,Lei Tan,Rongbao Gao,Jingdong Song,Xiang Gao,Xinlun Tian,Yingzhi Qin,Kai-Feng Xu,Dangsheng Li,Ningyi Jin,Chengyu Jiang +28 more
TL;DR: It is concluded that the autophagic cell death of alveolar epithelial cells likely plays a crucial role in the high mortality rate of H5N1 infection, and it is suggested that autophagy-blocking agents might be useful as prophylactics and therapeutics against infection of humans by the H 5N1 virus.
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mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
Yao-Song Gui,Lianmei Wang,Xinlun Tian,Xue Li,Aiping Ma,Weixun Zhou,Ni Zeng,Ji Zhang,Bai-qiang Cai,Hongbing Zhang,Jingyu Chen,Kai-Feng Xu +11 more
TL;DR: It is concluded that mTOR overactivation in AECs and compromised autophagy in the lungs are involved in the pathogenesis of pulmonary fibrosis and the suppression of mTOR and enhancement of Autophagy may be used for treatment of pulmonary Fibrosis.
Journal ArticleDOI
Lung function and systemic inflammation associated with short-term air pollution exposure in chronic obstructive pulmonary disease patients in Beijing, China
Nannan Gao,Wenshuai Xu,Jiadong Ji,Yanli Yang,Shao-Ting Wang,Jun Wang,Xiang Chen,Shuzhen Meng,Xinlun Tian,Kai-Feng Xu +9 more
TL;DR: Acute exposures to PM 2.5, NO 2, SO 2 and CO were associated with a reduction in FVC % pred in COPD patients and short-term exposure to air pollutants increased systemic inflammation in COPd patients; this may be attributed to increased Th1 and Th17 cytokines and decreased Th2 cytokines.