Y
Yanal Ghosheh
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 28
Citations - 1593
Yanal Ghosheh is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 8, co-authored 14 publications receiving 589 citations.
Papers
More filters
Journal ArticleDOI
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.
TL;DR: This fundamental discrepancy explains why most surface markers identified on in vitro generated macrophages do not translate to the in vivo situation and is justified by comparing the gene lists positively or negatively correlated with the ratio of IL-12 and arginase 1 in transcriptomes of LPS-treated peritoneal macrophades.
Journal ArticleDOI
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Alma Zernecke,Holger Winkels,Clément Cochain,Jesse W. Williams,Dennis Wolf,Oliver Soehnlein,Oliver Soehnlein,Clint S. Robbins,Claudia Monaco,Inhye Park,Coleen A. McNamara,Christoph J. Binder,Myron I. Cybulsky,Myron I. Cybulsky,Corey A. Scipione,Corey A. Scipione,Catherine C. Hedrick,Elena V. Galkina,Tin Kyaw,Tin Kyaw,Yanal Ghosheh,Huy Q. Dinh,Klaus Ley,Klaus Ley +23 more
TL;DR: A comprehensive meta-analysis of the diverse leukocyte infiltrate in atherosclerotic mouse aortas finds that monocytes, neutrophils, dendritic cells, natural killer cells, innate lymphoid cells-2, and CD (cluster of differentiation)-8 T cells form prominent and separate immune cell populations in atheosclerotic aorta.
Journal ArticleDOI
Single Cell RNA Sequencing in Atherosclerosis Research
Jesse W. Williams,Holger Winkels,Christopher P. Durant,Konstantin Zaitsev,Yanal Ghosheh,Klaus Ley,Klaus Ley +6 more
TL;DR: A technical guide for design, implementation, assembly, and interpretations of current single cell transcriptomics approaches from the perspective of employing these tools for advancing cardiovascular disease research is provided.
Journal ArticleDOI
Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100–Reactive CD4+ T-Regulatory Cells
Dennis Wolf,Dennis Wolf,Teresa Gerhardt,Teresa Gerhardt,Holger Winkels,Nathaly Anto Michel,Nathaly Anto Michel,Akula Bala Pramod,Akula Bala Pramod,Yanal Ghosheh,Simon Brunel,Konrad Buscher,Jacqueline Miller,Sara McArdle,Livia Baas,Kouji Kobiyama,Melanie Vassallo,Erik Ehinger,Thamotharampillai Dileepan,Amal J. Ali,Maximilian Schell,Zbigniew Mikulski,Daniel Sidler,Takayuki Kimura,Xia Sheng,Hauke Horstmann,Sophie Hansen,Lucia Sol Mitre,Peter Stachon,Ingo Hilgendorf,Dalia E. Gaddis,Catherine C. Hedrick,Chris A. Benedict,Bjoern Peters,Andreas Zirlik,Alessandro Sette,Klaus Ley +36 more
TL;DR: An unexpected mixed phenotype of apoB-reactive autoimmune T cells in atherosclerosis is demonstrated and an initially protective autoimmune response against apolipoprotein B100 with a progressive derangement in clinical disease is suggested.
Journal ArticleDOI
Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production
Marco Orecchioni,Kouji Kobiyama,Holger Winkels,Yanal Ghosheh,Sara McArdle,Zbigniew Mikulski,William B. Kiosses,Zhichao Fan,Lai Kai Wen,Yunmin Jung,Payel Roy,Amal J. Ali,Yukiko Miyamoto,Matthew Mangan,Jeffrey Makings,Zhihao Wang,Angela Denn,Jenifer Vallejo,M Owens,Christopher P. Durant,Simon Braumann,Navid Mader,Lin Li,Hiroaki Matsunami,Lars Eckmann,Eicke Latz,Zeneng Wang,Stanley L. Hazen,Klaus Ley +28 more
TL;DR: The authors find that mouse vascular macrophages express the olfactory receptor Olfr2 and all associated trafficking and signaling molecules, and suggest that inhibiting OR6A2 may provide a promising strategy to prevent and treat atherosclerosis.