Y
Yanhui Xu
Researcher at Fudan University Shanghai Medical College
Publications - 110
Citations - 9548
Yanhui Xu is an academic researcher from Fudan University Shanghai Medical College. The author has contributed to research in topics: Medicine & Heptad repeat. The author has an hindex of 38, co-authored 91 publications receiving 7605 citations. Previous affiliations of Yanhui Xu include Tsinghua University & Princeton University.
Papers
More filters
Journal ArticleDOI
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu,Hui Yang,Ying Liu,Ying Yang,Ping Wang,Se Hee Kim,Shinsuke Ito,Chen Yang,Pu Wang,Meng Tao Xiao,Li Xia Liu,Wen Qing Jiang,Jing Liu,Jin Ye Zhang,Bin Wang,Stephen V. Frye,Yi Zhang,Yanhui Xu,Qun-Ying Lei,Kun-Liang Guan,Shimin Zhao,Yue Xiong +21 more
TL;DR: 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases, leading to genome-wide histone and DNA methylation alterations.
Journal ArticleDOI
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao,Hui Yang,Wei Xu,Shenghong Ma,Huaipeng Lin,Honguang Zhu,Lixia Liu,Ying Liu,Chen Yang,Yanhui Xu,Shimin Zhao,Dan Ye,Yue Xiong,Kun-Liang Guan,Kun-Liang Guan +14 more
TL;DR: This study suggests that tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple α-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Journal ArticleDOI
Structure of the Protein Phosphatase 2A Holoenzyme.
Yanhui Xu,Yongna Xing,Yu Chen,Yang Chao,Zheng Lin,Eugene Fan,Jun Yu,Stefan Strack,Philip D. Jeffrey,Yigong Shi +9 more
TL;DR: The crystal structure of the heterotrimeric PP2A holoenzyme involving the regulatory subunit B'/B56/PR61, which comprises a scaffolding subunit and a catalytic subunit, is reported.
Journal ArticleDOI
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Lulu Hu,Ze Li,Jingdong Cheng,Qinhui Rao,Wei Gong,Mengjie Liu,Yujiang Geno Shi,Jiayu Zhu,Ping Wang,Yanhui Xu,Yanhui Xu +10 more
TL;DR: The crystal structure of human TET2 bound to methylated DNA at 2.02 Å resolution is presented and provides a structural basis for understanding the mechanisms of TET-mediated 5mC oxidation.
Journal ArticleDOI
Structural insights into the YAP and TEAD complex
Ze Li,Bin Zhao,Ping Wang,Fei Xavier Chen,Zhenghong Dong,Huirong Yang,Kun-Liang Guan,Yanhui Xu +7 more
TL;DR: The three-dimensional structure of the YAP-TEAD1 complex is reported, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces.