Hui Yang

TL;DR: 2-HG is a competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases, leading to genome-wide histone and DNA methylation alterations.

TL;DR: This study suggests that tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple α-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.

TL;DR: It is shown that cGAS mediates cellular senescence and retards immortalization, a cytosolic DNA sensor that activates innate immunity, which is distinct from, and complementary to, the role ofcGAS in activating antitumor immunity.

TL;DR: It is reported that cGAMP-induced autophagy is important for the clearance of DNA and viruses in the cytosol and Interestingly, STING from the sea anemone Nematostella vectensis inducesAutophagy but not interferons in response to stimulation by cGamp, which suggests that induction of autophileagy is a primordial function of the cGAS–STING pathway.

TL;DR: The levels of 5hmC are dramatically reduced in human breast, liver, lung, pancreatic and prostate cancers when compared with the matched surrounding normal tissues and the substantial reduction of the expression of all three TET genes is revealed, revealing a possible mechanism for the reduced5hmC in cancer cells.