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Yann Barrandon
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 80
Citations - 10836
Yann Barrandon is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Stem cell & Hair follicle. The author has an hindex of 41, co-authored 77 publications receiving 10311 citations. Previous affiliations of Yann Barrandon include University Hospital of Lausanne & University of Lausanne.
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Three clonal types of keratinocyte with different capacities for multiplication
Yann Barrandon,Howard Green +1 more
TL;DR: Colony-forming human epidermal cells are heterogeneous in their capacity for sustained growth and the incidence of the different clonal types is affected by aging, since cells originating from the epidermis of older donors give rise to a lower proportion of holoclones and a higher proportion of paraclones.
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Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
TL;DR: The results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
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Dominant role of the niche in melanocyte stem-cell fate determination
Emi K. Nishimura,Emi K. Nishimura,Siobhán A. Jordan,Hideo Oshima,Hideo Oshima,Hisahiro Yoshida,Masatake Osawa,Mariko Moriyama,Ian J. Jackson,Yann Barrandon,Yoshiki Miyachi,Shin-Ichi Nishikawa +11 more
TL;DR: It is reported that stem cells of the melanocyte lineage can be identified, using Dct-lacZ transgenic mice, in the lower permanent portion of mouse hair follicles throughout the hair cycle and indicated that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny.
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Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.
Stephane Chavanas,Christine Bodemer,Ariane Rochat,D. Hamel-Teillac,M Ali,Alan D. Irvine,Jean-Louis Bonafé,John D Wilkinson,Alain Taieb,Yann Barrandon,John I. Harper,Y. De Prost,Alain Hovnanian +12 more
TL;DR: A critical role of SPINK5 in epidermal barrier function and immunity is disclosed, and a new pathway for high serum IgE levels and atopic manifestations is suggested.
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Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
Yann Barrandon,Howard Green +1 more
TL;DR: In common methods of cell cultivation, multiplication takes place in cells distributed uniformly or in small colonies and the number of cells increases exponentially, but an isolated colony of coherent epidermal keratinocytes, as it grows larger, departs drastically from exponential growth, and instead increases its radius at a constant rate over time.