Y
Yarui Diao
Researcher at Duke University
Publications - 28
Citations - 3465
Yarui Diao is an academic researcher from Duke University. The author has contributed to research in topics: Chromatin & Enhancer. The author has an hindex of 20, co-authored 28 publications receiving 2481 citations. Previous affiliations of Yarui Diao include Hong Kong University of Science and Technology & University of California, San Diego.
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Journal ArticleDOI
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon,Inkyung Jung,Siddarth Selvaraj,Yin Shen,Jessica Antosiewicz-Bourget,Ah Young Lee,Zhen Ye,Audrey Kim,Nisha Rajagopal,Wei Xie,Yarui Diao,Jing Liang,Huimin Zhao,Victor V. Lobanenkov,Joseph R. Ecker,James A. Thomson,Bing Ren +16 more
TL;DR: Mapping genome-wide chromatin interactions in human embryonic stem cells and four human ES-cell-derived lineages reveals extensive chromatin reorganization during lineage specification, providing a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.
Journal ArticleDOI
Circular ecDNA promotes accessible chromatin and high oncogene expression
Sihan Wu,Kristen M. Turner,Nam Nguyen,Ramya Raviram,Marcella L. Erb,Jennifer Santini,Jens Luebeck,Utkrisht Rajkumar,Yarui Diao,Yarui Diao,Bin Li,Wenjing Zhang,Nathan M. Jameson,M. Ryan Corces,Jeffrey M. Granja,Xingqi Chen,Xingqi Chen,Ceyda Coruh,Armen Abnousi,Jack Houston,Zhen Ye,Rong Hu,Miao Yu,Hoon Kim,Julie A. Law,Roel G.W. Verhaak,Ming Hu,Frank B. Furnari,Howard Y. Chang,Howard Y. Chang,Bing Ren,Vineet Bafna,Paul S. Mischel +32 more
TL;DR: Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
Journal ArticleDOI
A compendium of promoter-centered long-range chromatin interactions in the human genome.
Inkyung Jung,Anthony D. Schmitt,Anthony D. Schmitt,Yarui Diao,Yarui Diao,Andrew J. Lee,Tristin Liu,Dongchan Yang,Catherine L. Tan,Junghyun Eom,Marilynn Chan,Sora Chee,Zachary Chiang,Changyoun Kim,Changyoun Kim,Eliezer Masliah,Eliezer Masliah,Cathy L. Barr,Bin Li,Samantha Kuan,Dongsup Kim,Bing Ren,Bing Ren +22 more
TL;DR: Mapping long-range chromatin interactions in 27 human cell/tissue types identifies candidate target genes of 70,329 putative regulatory elements and suggests potential regulatory function for 27,325 noncoding sequence variants associated with 2,117 physiological traits and diseases.
Journal ArticleDOI
RAP2 mediates mechanoresponses of the Hippo pathway
Zhipeng Meng,Yunjiang Qiu,Kimberly C. Lin,Aditya Kumar,Jesse K. Placone,Cao Fang,Kuei Chun Wang,Shicong Lu,Margaret Pan,Audrey W. Hong,Toshiro Moroishi,Toshiro Moroishi,Min Luo,Min Luo,Steven W. Plouffe,Yarui Diao,Zhen Ye,Hyun Woo Park,Hyun Woo Park,Xiaoqiong Wang,Fa-Xing Yu,Shu Chien,Cun-Yu Wang,Bing Ren,Bing Ren,Adam J. Engler,Kun-Liang Guan +26 more
TL;DR: The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ, thereby defining a mechanosignalling pathway from ECM stiffness to the nucleus.
Journal ArticleDOI
A tiling-deletion-based genetic screen for cis -regulatory element identification in mammalian cells
Yarui Diao,Rongxin Fang,Rongxin Fang,Bin Li,Zhipeng Meng,Juntao Yu,Juntao Yu,Yunjiang Qiu,Yunjiang Qiu,Kimberly C. Lin,Hui Huang,Hui Huang,Tristin Liu,Ryan J. Marina,Inkyung Jung,Yin Shen,Kun-Liang Guan,Bing Ren,Bing Ren +18 more
TL;DR: A high-throughput method, cis-regulatory element scan by tiling-deletion and sequencing (CREST-seq), is reported, used to interrogate the 2-Mb POU5F1 locus in human embryonic stem cells, and identified 45 cis-Regulatory elements, which point to the commonality of enhancer-like promoters in the human genome.