A
Ah Young Lee
Researcher at Ludwig Institute for Cancer Research
Publications - 33
Citations - 6392
Ah Young Lee is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Chromatin & Epigenomics. The author has an hindex of 22, co-authored 28 publications receiving 5199 citations. Previous affiliations of Ah Young Lee include University of California, San Diego & Hong Kong University of Science and Technology.
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Journal ArticleDOI
Chromatin architecture reorganization during stem cell differentiation
Jesse R. Dixon,Inkyung Jung,Siddarth Selvaraj,Yin Shen,Jessica Antosiewicz-Bourget,Ah Young Lee,Zhen Ye,Audrey Kim,Nisha Rajagopal,Wei Xie,Yarui Diao,Jing Liang,Huimin Zhao,Victor V. Lobanenkov,Joseph R. Ecker,James A. Thomson,Bing Ren +16 more
TL;DR: Mapping genome-wide chromatin interactions in human embryonic stem cells and four human ES-cell-derived lineages reveals extensive chromatin reorganization during lineage specification, providing a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages.
Journal ArticleDOI
A high-resolution map of the three-dimensional chromatin interactome in human cells
Fulai Jin,Yan Li,Jesse R. Dixon,Jesse R. Dixon,Siddarth Selvaraj,Siddarth Selvaraj,Zhen Ye,Ah Young Lee,Chia-An Yen,Anthony D. Schmitt,Anthony D. Schmitt,Celso A. Espinoza,Bing Ren,Bing Ren +13 more
TL;DR: A comprehensive chromatin interaction map generated in human fibroblasts using a genome-wide 3C analysis method (Hi-C) is reported and suggests that the three-dimensional chromatin landscape, once established in a particular cell type, is relatively stable and could influence the selection of target genes by a ubiquitous transcription activator in a cell-specific manner.
Journal ArticleDOI
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Wei Xie,Matthew D. Schultz,Ryan Lister,Zhonggang Hou,Nisha Rajagopal,Pradipta R. Ray,John W. Whitaker,Shulan Tian,R. David Hawkins,Danny Leung,Hongbo Yang,Tao Wang,Ah Young Lee,Scott Swanson,Jiuchun Zhang,Jiuchun Zhang,Yun Zhu,Audrey Kim,Joseph R. Nery,Mark A. Urich,Samantha Kuan,Chia-An Yen,Sarit Klugman,Pengzhi Yu,Kran Suknuntha,Nicholas E. Propson,Huaming Chen,Lee Edsall,Ulrich Wagner,Yan Li,Zhen Ye,Ashwinikumar Kulkarni,Zhenyu Xuan,Wen Yu Chung,Neil C. Chi,Jessica Antosiewicz-Bourget,Igor I. Slukvin,Ron Stewart,Michael Q. Zhang,Michael Q. Zhang,Wei Wang,James A. Thomson,James A. Thomson,James A. Thomson,Joseph R. Ecker,Bing Ren,Bing Ren +46 more
TL;DR: It is found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in nonexpressing lineages, while promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression.
Journal ArticleDOI
Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome
Wei Xie,Cathy L. Barr,Audrey Kim,Feng Yue,Ah Young Lee,James H. Eubanks,Emma Dempster,Emma Dempster,Bing Ren,Bing Ren +9 more
TL;DR: A base-resolution, allele-specific DNA methylation map in the mouse genome is generated, finding parent-of-origin dependent (imprinted) ASM at 1,952 CG dinucleotides and a surprising presence of non-CG methylation in the adult mouse brain, with some showing evidence of imprinting.
Journal ArticleDOI
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
John Arne Dahl,Inkyung Jung,Håvard Aanes,Gareth D. Greggains,Adeel Manaf,Mads Lerdrup,Guoqiang Li,Samantha Kuan,Bin Li,Ah Young Lee,Sebastian Preissl,Ingunn Jermstad,Mads H. Haugen,Rajikala Suganthan,Magnar Bjørås,Magnar Bjørås,Klaus Hansen,Knut Tomas Dalen,Peter Fedorcsak,Bing Ren,Bing Ren,Arne Klungland,Arne Klungland +22 more
TL;DR: A micro-scale chromatin immunoprecipitation and sequencing method is developed, which is used to profile genome-wide histone H3 lysine methylation and acetylation in mouse immature and metaphase II oocytes and in 2-cell and 8-cell embryos and demonstrates a role for broad H3K4me3 domains in MZT.