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Yasmeen Rahimi
Researcher at Yale University
Publications - 21
Citations - 3070
Yasmeen Rahimi is an academic researcher from Yale University. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 16, co-authored 21 publications receiving 2564 citations. Previous affiliations of Yasmeen Rahimi include Indiana University – Purdue University Indianapolis & Veterans Health Administration.
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Journal ArticleDOI
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Anila K. Madiraju,Derek M. Erion,Yasmeen Rahimi,Xian-Man Zhang,Demetrios T. Braddock,Ronald A. Albright,Brett J. Prigaro,John L. Wood,Sanjay Bhanot,Michael J. MacDonald,Michael J. Jurczak,Joao Paulo Camporez,Hui-Young Lee,Gary W. Cline,Varman T. Samuel,Richard G. Kibbey,Gerald I. Shulman +16 more
TL;DR: It is shown that metformin non-competitively inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase, resulting in an altered hepatocellular redox state, reduced conversion of lactate and glycerol to glucose, and decreased hepatic gluconeogenesis.
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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Keiyo Takubo,Go Nagamatsu,Chiharu I. Kobayashi,Ayako Nakamura-Ishizu,Hiroshi Kobayashi,Eiji Ikeda,Nobuhito Goda,Yasmeen Rahimi,Randall S. Johnson,Tomoyoshi Soga,Atsushi Hirao,Makoto Suematsu,Toshio Suda +12 more
TL;DR: In this paper, a pyruvate dehydrogenase kinase (Pdk)-dependent mechanism was found to regulate glycolytic metabolic status governed by Pdk, which acts as a cell cycle checkpoint that modifies HSC quiescence and function.
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Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy
Gaia Novarino,Paul El-Fishawy,Hülya Kayserili,Nagwa A. Meguid,Eric Scott,Jana Schroth,Jennifer L. Silhavy,Majdi Kara,Rehab O. Khalil,Tawfeg Ben-Omran,A. Gulhan Ercan-Sencicek,Adel F. Hashish,Stephen Sanders,Abha R. Gupta,Hebatalla S. Hashem,Dietrich Matern,Stacey Gabriel,Larry Sweetman,Yasmeen Rahimi,Robert A. Harris,Matthew W. State,Joseph G. Gleeson +21 more
TL;DR: Inactivating mutations in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) are identified in consanguineous families with autism, epilepsy, and intellectual disability and represents a potentially treatable syndrome.
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Bioluminescence-Based Detection of MicroRNA, miR21 in Breast Cancer Cells
TL;DR: The characteristics of the assay developed show its suitability for early cancer diagnosis based on miRNA as a biomarker and the utilization of the bioluminescent label, Rluc, that offers the advantage of high signal-to-noise ratio.
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Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler
Rachel J. Perry,Taehan Kim,Xian-Man Zhang,Hui-Young Lee,Dominik Pesta,Violeta B. Popov,Dongyan Zhang,Yasmeen Rahimi,Michael J. Jurczak,Gary W. Cline,David Spiegel,Gerald I. Shulman +11 more
TL;DR: It is demonstrated that the beneficial effects of DNP on hypertriglyceridemia, fatty liver, and insulin resistance can be dissociated from systemic toxicities and suggested the potential utility of liver-targeted mitochondrial uncoupling agents for the treatment of hypertrigenic fatty liver disease, NAFLD, metabolic syndrome, and T2D.