Y
Yasuharu Ninomiya
Researcher at Hiroshima University
Publications - 12
Citations - 524
Yasuharu Ninomiya is an academic researcher from Hiroshima University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 7 publications receiving 509 citations.
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Journal ArticleDOI
Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice
Koh Shinoda,Hong Lei,Hironori Yoshii,Masatoshi Nomura,Mamoru Nagano,Hiroharu Shiba,Hiroshi Sasaki,Yoshio Osawa,Yasuharu Ninomiya,Ohtsura Niwa,Ken Ichirou Morohashi,En Li +11 more
TL;DR: In this paper, double immunostaining of the pituitary for Ad4BP and trophic peptide hor- mones, FSH, TSH, and ACTH, indicated a re-stricted localization of the transcription factor to the gonadotroph.
Journal ArticleDOI
Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus.
Yi-Jun Fan,Z. Wang,S. Sadamoto,Yasuharu Ninomiya,Naoe Kotomura,Kenji Kamiya,Kiyohiko Dohi,Ryo Kominami,O. Niwa +8 more
TL;DR: Dose-response of an induction of a germline mutation was studied at a hypervariable mouse minisatellite locus, Ms6hm, which consists of tandem repeats of a sequence motif GGGCA, and the spermatids stage was most sensitive to radiation and a statistically significant dose-response was observed.
Journal ArticleDOI
Genomic organization and isoforms of the mouse ELP gene.
Yasuharu Ninomiya,Masahiro Okada,Naoe Kotomura,Katsnyuki Suzuki,Toshio Tsukiyama,Ohtsura Niwa +5 more
TL;DR: expression of the four ELP isoforms was studied in mouse tissues and in tissue culture cells by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and complex patterns of expression of these isoforms were observed in various tissues.
Journal Article
Association of Minisatellite Instability with c-myc Amplification and K-ras Mutation in Methylcholanthrene-induced Mouse Sarcomas
Ohtsura Niwa,Kenji Kamiya,Chie Furihata,Yumiko Nitta,Zhongwen Wang,Yi-Jun Fan,Yasuharu Ninomiya,Naoe Kotomura,Michitaka Numoto,Ryo Kominami +9 more
TL;DR: The present study indicates a possible involvement of K-ras mutation and c-myc amplification in induction of genetic instability in methylcholanthrene-induced mouse sarcomas.
Journal ArticleDOI
Transcriptional Regulation by Competition between ELP Isoforms and Nuclear Receptors
TL;DR: Interestingly, the activator-type ELP isoforms were capable of repressing retinoic acid-induced transactivation through binding to the retinoi acid receptor binding element, suggesting that competition for target DNA binding is a general mechanism of transcriptional repression by ELPisoforms.