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Yasuhisa Murai
Researcher at Hirosaki University
Publications - 23
Citations - 166
Yasuhisa Murai is an academic researcher from Hirosaki University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 11 publications receiving 34 citations.
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Journal ArticleDOI
Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Ukhyun Jo,Ilya S. Senatorov,Astrid Zimmermann,Liton Kumar Saha,Yasuhisa Murai,Se Hyun Kim,Vinodh N. Rajapakse,Fathi Elloumi,Nobuyuki Takahashi,Christopher W. Schultz,Anish Thomas,Frank Zenke,Yves Pommier +12 more
TL;DR: In this article, a new ATR-based chemotherapy drug, M4344, was proposed and compared with the clinically developed ATR inhibitors BAY1895344, berzosertib, and ceralasertib using in vitro and in vivo models.
Journal ArticleDOI
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.
Ukhyun Jo,Yasuhisa Murai,Sirisha Chakka,Lu Chen,Ken Cheng,Junko Murai,Liton Kumar Saha,Lisa M. Miller Jenkins,Yves Pommier +8 more
TL;DR: In this paper, the authors performed an unbiased genome-wide RNAi screen in SLFN11-WT and -knockout (KO) cells and found that inactivation of Ataxia Telangiectasia- and Rad3-related (ATR), CHK1, BRCA2, and RPA1 overcome chemoresistance to camptothecin (CPT) in cancer cells.
Journal ArticleDOI
SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.
Yasuhisa Murai,Ukhyun Jo,Junko Murai,Lisa M. Miller Jenkins,Shar-yin N. Huang,Sirisha Chakka,Lu Chen,Ken Cheng,Shinsaku Fukuda,Naoko Takebe,Yves Pommier +10 more
TL;DR: In this article, the authors conducted a drug screen with the NCATS mechanistic drug library of 1,978 compounds in isogenic SLFN11-knockout (KO) and wild-type (WT) leukemia cell lines and found that TAK-243, a first-in-class ubiquitin activating enzyme UBA1 inhibitor in clinical development, causes preferential cytotoxicity in SLFN-11-KO cells; this effect is associated with claspin-mediated DNA replication inhibition by CHK1 independently of ATR.
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Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes.
Liton Kumar Saha,Yasuhisa Murai,Sourav Saha,Ukhyun Jo,Masataka Tsuda,Masataka Tsuda,Shunichi Takeda,Yves Pommier +7 more
TL;DR: In this paper, the role of Spartan (SPRTN) is explored for DNA replication in human TK6 and chicken DT40 lymphoblastoid cells, and it is shown that SPRTN-deficient cells are hypersensitive to talazoparib and olaparib, but not to veliparib.
Journal ArticleDOI
Sa1653 THE USEFULNESS OF TOTAL INTESTINAL SURVEY USING COLON CAPSULE ENDOSCOPY~A FINAL REPORT ON THE TOTAL (TOTAL OBSERVATION FROM INTESTINE TO ANAL LESION) STUDY~
Hiroto Hiraga,Hirotake Sakuraba,Naoki Higuchi,Takato Maeda,Yasuhisa Murai,Rina Watanabe,Tetsuya Tatsuta,Keisuke Hasui,Hidezumi Kikuchi,Manabu Sawaya,Noriko Hiraga,Daisuke Chinda,Tatsuya Mikami,Shinsaku Fukuda +13 more