Yasushi Fukushima

TL;DR: KLF5 seems to be a key element linking external stress and cardiovascular remodeling, and that in vivo administration of RAR ligands affected stress responses in the cardiovascular system in a KLF5-dependent manner.

TL;DR: Investigation of the effects of chronic AII infusion on blood pressure and insulin sensitivity in rats fed a normal or high-salt diet suggests increased oxidative stress, possibly through impaired insulin signaling located downstream from PI 3-kinase activation, is involved in AII-induced insulin resistance.

TL;DR: The GLUT1 decrease may be involved in the dexamethasone-induced decrease in basal glucose transport activity, and the mechanism of dexamethylamethas one-induced insulin resistance in glucose transportactivity (rather than the inhibition of phosphatidylinositol 3-kinase activation resulting from a decreased IRS-1 content) is likely to underlie impaired glucose transporter regulation.

TL;DR: The data indicate that the SDF-1/CXCR4 pathway might be a general target for anticancer strategies and that blocking this system could be cooperatively effective in combination with other antiangiogenic therapies, such as blockade of VEGF.

TL;DR: It is found that resistin expression in 3T3-L1 adipocytes was significantly upregulated by high glucose concentrations and was suppressed by insulin, suggesting that these factors affect insulin sensitivity and fat tissue mass in part by altering the expression and eventual secretion of resistin from adipose cells.