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Yoshitomo Oka
Researcher at Tohoku University
Publications - 304
Citations - 21665
Yoshitomo Oka is an academic researcher from Tohoku University. The author has contributed to research in topics: Insulin & Glucose transporter. The author has an hindex of 77, co-authored 304 publications receiving 20519 citations. Previous affiliations of Yoshitomo Oka include Teikyo University & University of Queensland.
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Journal ArticleDOI
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms
Junichi Miyazaki,Kimi Araki,Eiji Yamato,Hiroshi Ikegami,Tomoichiro Asano,Yoshikazu Shibasaki,Yoshitomo Oka,Ken Ichi Yamamura +7 more
TL;DR: The MIN6 cell line will be especially useful to analyze the molecular mechanisms by which beta cells regulate insulin secretion in response to extracellular glucose concentrations, and a possible role of GT isoforms in glucose sensing by beta cells is discussed.
Journal ArticleDOI
International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values.
Atsunori Kashiwagi,Masato Kasuga,Eiichi Araki,Yoshitomo Oka,Toshiaki Hanafusa,Hiroshi Ito,Makoto Tominaga,Shinichi Oikawa,Mitsuhiko Noda,Takahiko Kawamura,Tokio Sanke,Mitsuyoshi Namba,Mitsuru Hashiramoto,Takayuki Sasahara,Yoshihiko Nishio,Katsuhiko Kuwa,Kohjiro Ueki,Izumi Takei,Masao Umemoto,Masami Murakami,Minoru Yamakado,Yutaka Yatomi,Hatsumi Ohashi +22 more
TL;DR: The JDS extensively evaluated the usefulness and feasibility of more extended use of HbA1c in the diagnosis of diabetes based on Japanese epidemiological data, and then the ‘Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus’ was published in the Journal of Diabetes Investigation5 and Diabetology International.
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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Kazuki Yasuda,Kazuaki Miyake,Yukio Horikawa,Hara Kazuo,Haruhiko Osawa,Hiroto Furuta,Yushi Hirota,Hiroyuki Mori,Anna Jonsson,Yoshifumi Sato,Kazuya Yamagata,Kazuya Yamagata,Yoshinori Hinokio,He-Yao Wang,Toshihito Tanahashi,Naoto Nakamura,Yoshitomo Oka,Naoko Iwasaki,Yasuhiko Iwamoto,Yuichiro Yamada,Yuichiro Yamada,Yutaka Seino,Yutaka Seino,Hiroshi Maegawa,Atsunori Kashiwagi,Jun Takeda,Eiichi Maeda,Hyoung Doo Shin,Young Min Cho,Kyong Soo Park,Hong Kyu Lee,Maggie C.Y. Ng,Ronald C.W. Ma,Wing-Yee So,Juliana C.N. Chan,Valeriya Lyssenko,Tiinamaija Tuomi,Peter M. Nilsson,Leif Groop,Leif Groop,Naoyuki Kamatani,Akihiro Sekine,Yusuke Nakamura,Ken Yamamoto,Yoshida Teruhiko,Katsushi Tokunaga,Mitsuo Itakura,Hideichi Makino,Kishio Nanjo,Takashi Kadowaki,Masato Kasuga +50 more
TL;DR: The data implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries as well as in two independent Japanese populations, and the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of β-cell function or the corrected insulin response.
Journal ArticleDOI
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
Hiroshi Inoue,Yukio Tanizawa,Jon Wasson,Philip Behn,Kamini Kalidas,Ernesto Bernal-Mizrachi,Mike Mueckler,Helen Marshall,Helen Donis-Keller,Patricia Crock,Douglas Rogers,Masahiko Mikuni,Hisashi Kumashiro,Koichiro Higashi,Gen Sobue,Yoshitomo Oka,M. Alan Permutt +16 more
TL;DR: In this paper, the authors localized the Wolfram syndrome (WFS) gene to a BAC/P1 contig of less than 250 kb and found that mutations in a novel gene encoding a putative transmembrane protein were associated with the disease phenotype.
Journal ArticleDOI
Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets.
Hisamitsu Ishihara,Tomoichiro Asano,Katsunori Tsukuda,Hideki Katagiri,Kouichi Inukai,Motonobu Anai,Masatoshi Kikuchi,Yoshio Yazaki,J.-I. Miyazaki,Yoshitomo Oka +9 more
TL;DR: Glucose-stimulated insulin secretion, glucose transport, glucose phosphorylation and glucose utilization have been characterized in the insulinoma cell line MIN6, indicating that this cell line is an appropriate model for studying the mechanism of glucose- stimulated insulin secretion in pancreatic beta cells.