Yehuda M. Danino

TL;DR: A broad spectrum of studies that highlight the importance of the core promoter and its pivotal role in the regulation of metazoan gene expression are reviewed and future research directions and challenges are suggested.

TL;DR: The Elements Navigation Tool (ElemeNT) is a user-friendly web-based, interactive tool for prediction and display of putative core promoter elements and their biologically-relevant combinations, and the CORE database summarizes ElemeNT-predicted core promoter Elements near CAGE and RNA-seq-defined Drosophila melanogaster transcription start sites (TSSs).

TL;DR: DAF-16 establishes alternative ER-associated degradation systems that degrade misfolded proteins independently of the ER stress sensor ire-1 and the ER- associated E3 ubiquitin ligase complex sel-11/sel-1, which can act together with the conserved UPR to improve ER homeostasis and ER stress resistance, beyond wild-type levels.

TL;DR: Genetic variants that protect against ALS by reducing neuroinflammation are revealed and the importance of noncoding genetic association studies are emphasized.

TL;DR: In this article , a convolutional neural network (CNN) was used to identify potential rG4s in transcriptomics data and showed that the CNN outperformed existing methods in both predicting rG 4 stability and detecting r G 4-forming sequences.