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Yelena Freyzon
Researcher at Massachusetts Institute of Technology
Publications - 10
Citations - 964
Yelena Freyzon is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Lipid droplet & Neurotoxicity. The author has an hindex of 8, co-authored 10 publications receiving 758 citations.
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Journal ArticleDOI
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
Chee Yeun Chung,Vikram Khurana,Vikram Khurana,Pavan K. Auluck,Pavan K. Auluck,Daniel F. Tardiff,Joseph R. Mazzulli,Frank Soldner,Valeriya Baru,Yali Lou,Yelena Freyzon,Sukhee Cho,Alison E. Mungenast,Julien Muffat,Maisam Mitalipova,Michael D. Pluth,Nathan T. Jui,Birgitt Schüle,Stephen J. Lippard,Li-Huei Tsai,Li-Huei Tsai,Dimitri Krainc,Stephen L. Buchwald,Rudolf Jaenisch,Susan Lindquist +24 more
TL;DR: In this paper, the authors exploited mutation correction of iPS cells and conserved proteotoxic mechanisms from yeast to humans to discover and reverse phenotypic responses to α-synuclein (αsyn), a key protein involved in Parkinson's disease (PD).
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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Saranna Fanning,Saranna Fanning,Aftabul Haque,Thibaut Imberdis,Valeriya Baru,M. Inmaculada Barrasa,Silke Nuber,Daniel Termine,Nagendran Ramalingam,Gary P.H. Ho,Tallie Noble,Jackson Sandoe,Yali Lou,Dirk Landgraf,Yelena Freyzon,Gregory A. Newby,Frank Soldner,Elizabeth Terry-Kantor,Tae-Eun Kim,Harald F. Hofbauer,Michel Becuwe,Rudolf Jaenisch,David Pincus,Clary B. Clish,Tobias C. Walther,Robert V. Farese,Supriya Srinivasan,Supriya Srinivasan,Michael A. Welte,Sepp D. Kohlwein,Ulf Dettmer,Susan Lindquist,Dennis J. Selkoe +32 more
TL;DR: Monounsaturated fatty acid metabolism is pivotal for αS-induced neurotoxicity, and inhibiting SCD represents a novel PD therapeutic approach.
Journal ArticleDOI
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
Vikram Khurana,Vikram Khurana,Vikram Khurana,Jian Peng,Chee Yeun Chung,Pavan K. Auluck,Saranna Fanning,Daniel F. Tardiff,Theresa Bartels,Martina Koeva,Stephen W. Eichhorn,Hadar Benyamini,Yali Lou,Andy Nutter-Upham,Valeriya Baru,Yelena Freyzon,Nurcan Tuncbag,Michael Costanzo,Bryan Joseph San Luis,David C. Schöndorf,M. Inmaculada Barrasa,Sepehr Ehsani,Neville E. Sanjana,Neville E. Sanjana,Quan Zhong,Thomas Gasser,David P. Bartel,Marc Vidal,Michela Deleidi,Charles Boone,Ernest Fraenkel,Bonnie Berger,Susan Lindquist +32 more
TL;DR: This cross-species platform connected diverse neurodegenerative genes to proteinopathy through specific mechanisms and may facilitate patient stratification for targeted therapy.
Journal ArticleDOI
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons
Chee Yeun Chung,Vikram Khurana,Vikram Khurana,Song Yi,Nidhi Sahni,Ken H. Loh,Pavan K. Auluck,Valeriya Baru,Namrata D. Udeshi,Yelena Freyzon,Steven A. Carr,David E. Hill,Marc Vidal,Alice Y. Ting,Susan Lindquist +14 more
TL;DR: Using an ascorbate peroxidase (APEX)-based labeling method combined with mass spectrometry, a network of proteins in the immediate vicinity of α-syn in living neurons was defined to shed light on α- Synucleinopathies.
Journal ArticleDOI
Detecting force-induced molecular transitions with fluorescence resonant energy transfer.
Peter B. Tarsa,Ricardo R. Brau,Mariya,Jorge Ferrer,Yelena Freyzon,Paul Matsudaira,Matthew J. Lang +6 more
TL;DR: This work describes the first combination of optical-tweezers force microscopy with the single-molecule FRET detection of a novel force-sensing molecule into a single, integrated method capable of actively controlling molecular structure while simultaneously monitoring the conformational state of a single DNA hairpin molecule.