B
Birgitt Schüle
Researcher at Stanford University
Publications - 81
Citations - 6096
Birgitt Schüle is an academic researcher from Stanford University. The author has contributed to research in topics: LRRK2 & Parkinson's disease. The author has an hindex of 35, co-authored 77 publications receiving 4980 citations. Previous affiliations of Birgitt Schüle include University of Lübeck & Howard Hughes Medical Institute.
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Journal ArticleDOI
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Ha Nam Nguyen,Blake Byers,Branden J. Cord,Aleksandr Shcheglovitov,James A. Byrne,Prachi Gujar,Kehkooi Kee,Birgitt Schüle,Ricardo E. Dolmetsch,William Langston,Theo D. Palmer,Renee A. Reijo Pera +11 more
TL;DR: Generation of induced pluripotent stem cells that carry the p.G2019S mutation in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene and their differentiation into DA neurons found that DA neurons derived from G2019S-iPSCs showed increased expression of key oxidative stress-response genes and α-synuclein protein.
Journal ArticleDOI
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.
Julia Fuchs,Christer Nilsson,Jennifer M. Kachergus,Marita Munz,Elna-Marie Larsson,Birgitt Schüle,J. W. Langston,Frank A. Middleton,Owen A. Ross,Mary M. Hulihan,Thomas Gasser,Matthew J. Farrer +11 more
TL;DR: The genetic basis for familial parkinsonism is an SNCA-MMRN11 multiplication, but whereas the Swedish proband leads to late-onset autonomic dysfunction and parkinsonist, the Swedish American family (Branch I) leads to early-onsets Parkinson disease and dementia.
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Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
Chee Yeun Chung,Vikram Khurana,Vikram Khurana,Pavan K. Auluck,Pavan K. Auluck,Daniel F. Tardiff,Joseph R. Mazzulli,Frank Soldner,Valeriya Baru,Yali Lou,Yelena Freyzon,Sukhee Cho,Alison E. Mungenast,Julien Muffat,Maisam Mitalipova,Michael D. Pluth,Nathan T. Jui,Birgitt Schüle,Stephen J. Lippard,Li-Huei Tsai,Li-Huei Tsai,Dimitri Krainc,Stephen L. Buchwald,Rudolf Jaenisch,Susan Lindquist +24 more
TL;DR: In this paper, the authors exploited mutation correction of iPS cells and conserved proteotoxic mechanisms from yeast to humans to discover and reverse phenotypic responses to α-synuclein (αsyn), a key protein involved in Parkinson's disease (PD).
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Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease
Chung Han Hsieh,Atossa Shaltouki,Ashley E. Gonzalez,Alexandre Bettencourt da Cruz,Lena F. Burbulla,Erica St. Lawrence,Birgitt Schüle,Dimitri Krainc,Theo D. Palmer,Xinnan Wang +9 more
TL;DR: It is shown that a third PD-related protein, LRRK2, promotes Miro removal by forming a complex with Miro, and this may constitute a central component of PD pathogenesis.
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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Shuchi Mittal,Kjetil Bjornevik,Kjetil Bjornevik,Doo Soon Im,Adrian Flierl,Xianjun Dong,Joseph J. Locascio,Joseph J. Locascio,Kristine M. Abo,Elizabeth Long,Ming Jin,Bing Xu,Yang Kevin Xiang,Jean-Christophe Rochet,Anders Engeland,Anders Engeland,Patrizia Rizzu,Peter Heutink,Tim Bartels,Dennis J. Selkoe,Barbara J. Caldarone,Barbara J. Caldarone,Marcie A. Glicksman,Vikram Khurana,Vikram Khurana,Birgitt Schüle,David S. Park,Trond Riise,Trond Riise,Clemens R. Scherzer +29 more
TL;DR: It is discovered that the β2-adrenoreceptor (β2AR) is a regulator of the α-synuclein gene (SNCA) and constitutes a potential target for therapies in Parkinson’s disease.