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Yi-Chao Zheng
Researcher at Zhengzhou University
Publications - 76
Citations - 2385
Yi-Chao Zheng is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Cancer & Demethylase. The author has an hindex of 21, co-authored 64 publications receiving 1593 citations. Previous affiliations of Yi-Chao Zheng include Chinese Ministry of Education.
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Journal ArticleDOI
Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration
Yi-Chao Zheng,Ying-Chao Duan,Jin-Lian Ma,Rui-Min Xu,Xiaolin Zi,Wen-Lei Lv,Meng-Meng Wang,Xian-Wei Ye,Shun Zhu,David L. Mobley,Yan-Yan Zhu,Jun-Wei Wang,Jinfeng Li,Zhi-Ru Wang,Wen Zhao,Hong-Min Liu +15 more
TL;DR: Five series of 1,2,3-triazole-dithiocarbamate hybrids were designed and synthesized and screened their inhibitory activity toward LSD1 and it was found that some of these compounds exhibited the most specific and robust inhibition of LSD1.
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A Systematic Review of Histone Lysine-Specific Demethylase 1 and Its Inhibitors.
Yi-Chao Zheng,Jin-Lian Ma,Zhi-Ru Wang,Jinfeng Li,Bai-Ling Jiang,Wenjuan Zhou,Xiao-Jing Shi,Wang Xixin,Wen Zhao,Hong-Min Liu +9 more
TL;DR: A review of recent studies about LSD1 focuses on the basic physiological function of LSD1 and its involved mechanisms in pathophysiologic conditions, as well as the development of LSD 1 inhibitors as potential anticancer therapeutic agents.
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Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents
Li-Ying Ma,Yi-Chao Zheng,Sai-Qi Wang,Bo Wang,Zhi-Ru Wang,L. Pang,Miao Zhang,Jun-Wei Wang,Lina Ding,Juan Li,Cong Wang,Biao Hu,Ying Liu,Xiao-Dan Zhang,Jia-Jia Wang,Zhi-Jian Wang,Wen Zhao,Hong-Min Liu +17 more
TL;DR: Findings indicate that the pyrimidine-thiourea-based LSD1 inactivator may serve as a leading compound targeting LSD1 overexpressed cancers.
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Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents
TL;DR: This work focuses on illustrating the discovery of SAR405838, RO8994, CFI-400945 and their bioisosteres for cancer therapy using substructure-based strategies and discussing modes of action, binding models and preclinical data.
Journal ArticleDOI
Design, synthesis and antiproliferative activity studies of novel 1,2,3-triazole–dithiocarbamate–urea hybrids
Ying-Chao Duan,Yi-Chao Zheng,Xiao-Chen Li,Meng-Meng Wang,Xian-Wei Ye,Yuan-Yuan Guan,Gai-Zhi Liu,Jiaxin Zheng,Hong-Min Liu +8 more
TL;DR: A series of novel 1,2,3-triazole-dithiocarbamate-urea hybrids were designed, synthesized and their antiproliferative activities against four selected human cancer cell lines were evaluated and showed that a number of the hybrids exhibited potent activity in selected humancancer cell lines.