Y
Yi Xu
Researcher at National Institutes of Health
Publications - 71
Citations - 3069
Yi Xu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Amniotic fluid & Inflammation. The author has an hindex of 30, co-authored 57 publications receiving 2198 citations. Previous affiliations of Yi Xu include Wayne State University.
Papers
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Journal ArticleDOI
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1.
Roberto Romero,Tinnakorn Chaiworapongsa,Zeynep Alpay Savasan,Yi Xu,Youssef Hussein,Zhong Dong,Juan Pedro Kusanovic,Chong Jai Kim,Sonia S. Hassan +8 more
TL;DR: This study determined whether intra-amniotic infection/inflammation (IAI) is associated with changes in amniotic fluid concentrations of HMGB1; and localize immunoreactivity ofHMGB1 in the fetal membranes and umbilical cord of patients with chorioamnionitis.
Journal ArticleDOI
Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
Pooja Mittal,Roberto Romero,Roberto Romero,Adi L. Tarca,Adi L. Tarca,Juan M. Gonzalez,Juan M. Gonzalez,Sorin Draghici,Yi Xu,Zhong Dong,Chia Ling Nhan-Chang,Chia Ling Nhan-Chang,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Stephen J. Lye,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Leonard Lipovich,Shali Mazaki-Tovi,Shali Mazaki-Tovi,Sonia S. Hassan,Sonia S. Hassan,Sam Mesiano,Chong Jai Kim,Chong Jai Kim +24 more
TL;DR: Myometrium of women in spontaneous labor at term is characterized by a stereotypic gene expression pattern consistent with over-expression of the inflammatory response and leukocyte chemotaxis.
Journal ArticleDOI
An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment.
Yi Xu,Roberto Romero,Derek Miller,Leena Kadam,Tara N. Mial,Tara N. Mial,Olesya Plazyo,Valeria Garcia-Flores,Valeria Garcia-Flores,Sonia S. Hassan,Sonia S. Hassan,Zhonghui Xu,Zhonghui Xu,Adi L. Tarca,Adi L. Tarca,Sascha Drewlo,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +17 more
TL;DR: It is demonstrated that decidual M1-like macrophages are associated with spontaneous preterm labor and that PPARγ activation via RSG can attenuate the macrophage-mediated proinflammatory response, preventing preterm birth and improving neonatal outcomes.
Journal ArticleDOI
A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d
JoonHo Lee,Roberto Romero,Roberto Romero,Yi Xu,Jung Sun Kim,Vanessa Topping,Wonsuk Yoo,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Sonia S. Hassan,Sonia S. Hassan,Bo Hyun Yoon,Chong Jai Kim,Chong Jai Kim +15 more
TL;DR: A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions.
Journal ArticleDOI
Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?
Nardhy Gomez-Lopez,Nardhy Gomez-Lopez,Roberto Romero,Yi Xu,Yi Xu,Yaozhu Leng,Yaozhu Leng,Valeria Garcia-Flores,Derek Miller,Derek Miller,Suzanne M. Jacques,Suzanne M. Jacques,Sonia S. Hassan,Sonia S. Hassan,Jonathan Faro,Adham Alsamsam,Ali Alhousseini,Hunter Gomez-Roberts,Bogdan Panaitescu,Bogdan Panaitescu,Lami Yeo,Lami Yeo,Eli Maymon,Eli Maymon +23 more
TL;DR: Evidence is provided that both fetal and maternal neutrophils can invade the amniotic cavity, suggesting that both the fetus and the mother participate in the host defense mechanisms against intraamniotic infection.