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Yaozhu Leng
Researcher at National Institutes of Health
Publications - 29
Citations - 1566
Yaozhu Leng is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Fetus & Inflammasome. The author has an hindex of 17, co-authored 27 publications receiving 903 citations. Previous affiliations of Yaozhu Leng include Wayne State University.
Papers
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Journal ArticleDOI
Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Roger Pique-Regi,Roger Pique-Regi,Roberto Romero,Adi L. Tarca,Adi L. Tarca,Adi L. Tarca,Francesca Luca,Yi Xu,Yi Xu,Adnan Alazizi,Yaozhu Leng,Yaozhu Leng,Chaur-Dong Hsu,Chaur-Dong Hsu,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +15 more
TL;DR: It is reported that co-transcription of ACE2 and TMPRSS2 is negligible in the placenta, thus not a likely path of vertical transmission for SARS-CoV-2.
Journal ArticleDOI
Single cell transcriptional signatures of the human placenta in term and preterm parturition.
Roger Pique-Regi,Roger Pique-Regi,Roberto Romero,Adi L. Tarca,Adi L. Tarca,Edward Sendler,Yi Xu,Yi Xu,Valeria Garcia-Flores,Valeria Garcia-Flores,Yaozhu Leng,Yaozhu Leng,Francesca Luca,Sonia S. Hassan,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +15 more
TL;DR: A catalogue of cell types and transcriptional profiles in the human placenta is provided, shedding light on the molecular underpinnings and non-invasive prediction of the physiologic and pathologic parturition.
Journal ArticleDOI
Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?
Nardhy Gomez-Lopez,Nardhy Gomez-Lopez,Roberto Romero,Yi Xu,Yi Xu,Yaozhu Leng,Yaozhu Leng,Valeria Garcia-Flores,Derek Miller,Derek Miller,Suzanne M. Jacques,Suzanne M. Jacques,Sonia S. Hassan,Sonia S. Hassan,Jonathan Faro,Adham Alsamsam,Ali Alhousseini,Hunter Gomez-Roberts,Bogdan Panaitescu,Bogdan Panaitescu,Lami Yeo,Lami Yeo,Eli Maymon,Eli Maymon +23 more
TL;DR: Evidence is provided that both fetal and maternal neutrophils can invade the amniotic cavity, suggesting that both the fetus and the mother participate in the host defense mechanisms against intraamniotic infection.
Posted ContentDOI
Single Cell Transcriptional Signatures of the Human Placenta in Term and Preterm Parturition
Roger Pique-Regi,Roger Pique-Regi,Roberto Romero,Adi L. Tarca,Adi L. Tarca,Adi L. Tarca,Edward Sendler,Yi Xu,Yi Xu,Valeria Garcia-Flores,Valeria Garcia-Flores,Yaozhu Leng,Yaozhu Leng,Francesca Luca,Sonia S. Hassan,Sonia S. Hassan,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +17 more
TL;DR: A catalogue of cell types and transcriptional profiles in the human placenta is provided, shedding light on the molecular underpinnings and non-invasive prediction of the physiologic and pathologic parturition.
Journal ArticleDOI
Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2
Valeria Garcia-Flores,Roberto Romero,Yi Xu,Kevin R. Theis,Marcia Arenas-Hernandez,Derek Miller,Azam Peyvandipour,Gaurav Bhatti,Jose Galaz,Meyer Gershater,Dustyn Levenson,Errile Pusod,L Tao,David Kracht,Violetta Florova,Yaozhu Leng,Kenichiro Motomura,Robert Para,M. G. M. Faucett,Chaur-Dong Hsu,Gary Zhang,Adi L. Tarca,Roger Pique-Regi,Nardhy Gomez-Lopez +23 more
TL;DR: This paper showed that SARS-CoV-2 infection during pregnancy primarily induces unique inflammatory responses at the maternal-fetal interface, which are largely governed by maternal T cells and fetal stromal cells.