Ying Xiong

TL;DR: Genetic and pharmacological inhibition of the tubulin-specific deacetylase activity of HDAC6 indicates that the rescue effect may be mediated by increased MT acetylation, revealing HDAC 6 as a unique potential drug target for AD and related tauopathies.

TL;DR: This study provides strong evidence of 'ghost introgression' as the cause of DMD, and it is suggested that ' ghost introgressive' may be a widely overlooked phenomenon in nature.

TL;DR: It was shown that adaptive convergence in all 3 high-altitude species seldom occurred at the amino acid substitution level but was more common on positively selected genes, and an altitude-related expression pattern was observed in genes differentially expressed between all 3 species pairs and genes associated with altitude, suggesting that the high-ALTitude environment may drive similar expression shifts in the 3high-altitudes species.

TL;DR: The results demonstrate for the first time that Katanin 60 is required for the normal development of neuromuscular synapses and dendrites in Drosophila.

TL;DR: A case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution is revealed, shedding light on early stages of adaptive evolution to a novel environment.