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Weiwei Zhai
Researcher at Chinese Academy of Sciences
Publications - 55
Citations - 7701
Weiwei Zhai is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 21, co-authored 49 publications receiving 6120 citations. Previous affiliations of Weiwei Zhai include Beijing Institute of Genomics & Nanyang Technological University.
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Journal ArticleDOI
A Draft Sequence of the Neandertal Genome
Richard E. Green,Johannes Krause,Adrian W. Briggs,Tomislav Maricic,Udo Stenzel,Martin Kircher,Nick Patterson,Heng Li,Weiwei Zhai,Markus Hsi-Yang Fritz,Nancy F. Hansen,Eric Durand,Anna-Sapfo Malaspinas,Jeffrey D. Jensen,Tomas Marques-Bonet,Tomas Marques-Bonet,Can Alkan,Kay Prüfer,Matthias Meyer,Hernán A. Burbano,Jeffrey M. Good,Jeffrey M. Good,Rigo Schultz,Ayinuer Aximu-Petri,Anne Butthof,Barbara Höber,Barbara Höffner,Madien Siegemund,Antje Weihmann,Chad Nusbaum,Eric S. Lander,Carsten Russ,Nathaniel Novod,Jason P. Affourtit,Michael Egholm,Christine Verna,Pavao Rudan,Dejana Brajković,Željko Kućan,Ivan Gušić,Vladimir B. Doronichev,Liubov V. Golovanova,Carles Lalueza-Fox,Marco de la Rasilla,Javier Fortea,Antonio Rosas,Ralf Schmitz,Philip L. F. Johnson,Evan E. Eichler,Daniel Falush,Ewan Birney,James C. Mullikin,Montgomery Slatkin,Rasmus Nielsen,Janet Kelso,Michael Lachmann,David Reich,David Reich,Svante Pääbo +58 more
TL;DR: The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Journal ArticleDOI
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni,Etienne Becht,Michael G. Fehlings,Chiew Yee Loh,Si-Lin Koo,Karen Wei Weng Teng,Joe Poh Sheng Yeong,Joe Poh Sheng Yeong,Rahul Nahar,Tong Zhang,Hassen Kared,Kaibo Duan,Nicholas Ang,Michael Poidinger,Yin Yeng Lee,Anis Larbi,Alexis Jiaying Khng,Emile Tan,Cherylin Fu,Ronnie Mathew,Melissa Ching Ching Teo,Wan-Teck Lim,Chee Keong Toh,Boon-Hean Ong,Tina Koh,Axel M. Hillmer,Angela Takano,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Eng Huat Tan,Weiwei Zhai,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Evan W. Newell +37 more
TL;DR: It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Journal ArticleDOI
An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia
Morten Rasmussen,Xiaosen Guo,Yong Wang,Kirk E. Lohmueller,Simon Rasmussen,Anders Albrechtsen,Line Skotte,Stinus Lindgreen,Mait Metspalu,Thibaut Jombart,Toomas Kivisild,Weiwei Zhai,Anders Eriksson,Andrea Manica,Ludovic Orlando,Francisco M. De La Vega,Silvana R. Tridico,Ene Metspalu,Kasper Nielsen,María C. Ávila-Arcos,J. Víctor Moreno-Mayar,J. Víctor Moreno-Mayar,Craig Muller,Joe Dortch,M. Thomas P. Gilbert,Ole Lund,Agata Wesolowska,Monika Karmin,Lucy A. Weinert,Bo Wang,Jun Li,Shuaishuai Tai,Fei Xiao,Tsunehiko Hanihara,George van Driem,Aashish R. Jha,François-Xavier Ricaut,Peter de Knijff,Andrea Bamberg Migliano,Andrea Bamberg Migliano,Irene Gallego Romero,Karsten Kristiansen,David M. Lambert,Søren Brunak,Søren Brunak,Peter Forster,Bernd Brinkmann,Olaf Nehlich,Michael Bunce,Michael P. Richards,Michael P. Richards,Ramneek Gupta,Carlos Bustamante,Anders Krogh,Robert Foley,Marta Mirazón Lahr,Francois Balloux,Thomas Sicheritz-Pontén,Richard Villems,Richard Villems,Rasmus Nielsen,Rasmus Nielsen,Jun Wang,Eske Willerslev +63 more
TL;DR: It is shown that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago, which is separate from the one that gave rise to modern Asians 25, thousands of years ago.
Journal ArticleDOI
The genomics of selection in dogs and the parallel evolution between dogs and humans
Guo-Dong Wang,Weiwei Zhai,He-Chuan Yang,He-Chuan Yang,Ruo-xi Fan,Xue Cao,Li Zhong,Lu Wang,Fei Liu,Hong Wu,Lu-Guang Cheng,Andrei D. Poyarkov,Nikolai A. Poyarkov,Shu-sheng Tang,Wenming Zhao,Yun Gao,Xue-mei Lv,David M. Irwin,David M. Irwin,Peter Savolainen,Chung-I Wu,Chung-I Wu,Ya-Ping Zhang,Ya-Ping Zhang,Ya-Ping Zhang +24 more
TL;DR: This study draws together humans and dogs in their recent genomic evolution, for the first time, and identifies a list of genes under positive selection during domestication, which overlaps extensively with the corresponding list of positively selected genes in humans.
Journal ArticleDOI
Out of southern East Asia: the natural history of domestic dogs across the world.
Guo-Dong Wang,Weiwei Zhai,He-Chuan Yang,He-Chuan Yang,He-Chuan Yang,Lu Wang,Li Zhong,Yan-Hu Liu,Ruo-xi Fan,Ting-Ting Yin,Ting-Ting Yin,Chun-Ling Zhu,Andrei D. Poyarkov,David M. Irwin,Marjo K. Hytönen,Hannes Lohi,Chung-I Wu,Peter Savolainen,Ya-Ping Zhang,Ya-Ping Zhang +19 more
TL;DR: It is found that dogs from southern East Asia have significantly higher genetic diversity compared to other populations, and are the most basal group relating to gray wolves, indicating an ancient origin of domestic dogs in southern EastAsia 33 000 years ago.