Ying Yin

TL;DR: It is suggested chimeric HBc particles carrying a neutralizing epitope of PA can induce protective immunity against Bacillus anthracis, and was able to partially protect the immunized guinea pigs against virulent anthrax spores challenge.

TL;DR: This research successfully inserted the 2β2-2β3 loop of PA into the major immunodominant region (MIR) of hepatitis B virus core (HBc) protein, and removed amino acids 79-81 from the HBc MIR of theHBcL2, leading to the full protection of the immunized mice against a lethal dose anthrax toxin challenge.

TL;DR: A mass spectrometry-based label-free relative quantitative proteomics approach is utilized to investigate and compare global proteomic changes in B. abortus in response to eight different stress treatments, providing a better understanding of the global metabolic adaptations of B. abortion associated with distinct environmental stresses.

TL;DR: Investigating the PA domain specificity, affinity, mechanisms of neutralization, and synergistic effects of PA-specific antibodies from a single donor following vaccination with the rPA vaccine provides novel insights into the antibody response elicited by the r PA vaccine and may be useful for PA-based vaccine and immunotherapeutic cocktail design.

TL;DR: A bivalent vaccine where the G proteins of NiV and HeV were fused with the human IgG1 Fc domain and a tetravalent Fc heterodimer fusion protein that contains the G protein domains of four HNVs is constructed, suggesting efficient candidates to prevent HNV infection.