Y
Yoichi Shinkai
Researcher at Kyoto University
Publications - 151
Citations - 20526
Yoichi Shinkai is an academic researcher from Kyoto University. The author has contributed to research in topics: Histone methyltransferase & Histone H3. The author has an hindex of 57, co-authored 142 publications receiving 18744 citations.
Papers
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Journal ArticleDOI
Thy-1-positive dendritic epidermal cells contain a killer protein perforin.
Tetsuji Kobata,Yoichi Shinkai,Yutaka Iigo,Akemi Kawasaki,Hideo Yagita,Seiga Ito,Shinji Shimada,Stephen I. Katz,Ko Okumura +8 more
TL;DR: The killer cell characteristics of Thy-1-positive dendritic epidermal cells (Thy-1+ DEC) were examined and it is suggested that Thy- 1+ DEC may play a cytotoxic role in protecting the integrity of skin from infection or neoplastic transformation.
Journal ArticleDOI
alpha1,3-Galactosyltransferase-gene knockout in cattle using a single targeting vector with loxP sequences and cre-expressing adenovirus.
Yutaka Sendai,Tokihiko Sawada,M. Urakawa,Yoichi Shinkai,Keiichi Kubota,Hiroyoshi Hoshi,Yoshito Aoyagi +6 more
TL;DR: This method should be useful for future production of knockouts of multiple genes in livestock and is faster and more economical than backcrossing to produce homozygous knockouts.
Journal ArticleDOI
Cellular and molecular bases for the immunopathology of the myocardial cell damage involved in acute viral myocarditis with special reference to dilated cardiomyopathy.
Yoshinori Seko,Tsutomu Yamazaki,Yoichi Shinkai,Hideo Yagita,Ko Okumura,Shigeto Naito,Kouji Imataka,Jun Fujii,Yoshio Yazaki +8 more
TL;DR: Data provided direct evidence that cell-mediated cytotoxicity plays a critical role in the myocardial cell damage involved in viral myocarditis, as Immunoelectron microscopic study showed killer cells directly damaging cardiac myocytes by the release of perforin.
Journal ArticleDOI
Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis.
Takuma Nakatsuka,Keisuke Tateishi,Hiroyuki S. Kato,Hiroaki Fujiwara,Keisuke Yamamoto,Yotaro Kudo,Hayato Nakagawa,Yasuo Tanaka,Hideaki Ijichi,Tsuneo Ikenoue,Takeaki Ishizawa,Kiyoshi Hasegawa,Makoto Tachibana,Yoichi Shinkai,Kazuhiko Koike +14 more
TL;DR: In this article, the pivotal role of histone methyltransferase G9a in the DNA damage-triggered initiation of hepatocellular carcinoma (HCC) was identified.
Book ChapterDOI
Regulation and function of H3K9 methylation.
TL;DR: In this chapter, histone H3 lysine 9 specific methyltransferases will be discussed as model enzymes involved in the regulation of chromatin function in different eukaryotes.