Y
Yoichi Shinkai
Researcher at Kyoto University
Publications - 151
Citations - 20526
Yoichi Shinkai is an academic researcher from Kyoto University. The author has contributed to research in topics: Histone methyltransferase & Histone H3. The author has an hindex of 57, co-authored 142 publications receiving 18744 citations.
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Journal ArticleDOI
The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.
Shang Cao,Heather H. Bendall,Geoffrey G. Hicks,Abudi Nashabi,Hitoshi Sakano,Yoichi Shinkai,Marisa Gariglio,Eugene M. Oltz,H. Earl Ruley +8 more
TL;DR: Ssrp1 appears to encode nonredundant and p53-independent functions that are essential for cell viability, and is implicated in DNA replication, basal and regulated transcription, and DNA repair.
Journal ArticleDOI
Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly.
Atsuko Shirai,Takayuki Kawaguchi,Takayuki Kawaguchi,Hideaki Shimojo,Daisuke Muramatsu,Mayumi Ishida-Yonetani,Yoshifumi Nishimura,Hiroshi Kimura,Jun-ichi Nakayama,Jun-ichi Nakayama,Yoichi Shinkai +10 more
TL;DR: It is suggested that chromatin-bound RNAs contribute to creating SUV39H’s target specificity, and both nucleic acid–binding and H3K9me–binding activities of Suv39h1-CD were crucial for its pericentric heterochromatin assembly.
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Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hideharu Hashimoto,Yasunari Takami,Eiichiro Sonoda,Tomohito Iwasaki,Hidetomo Iwano,Makoto Tachibana,Shunichi Takeda,Tatsuo Nakayama,Hiroshi Kimura,Yoichi Shinkai +9 more
TL;DR: It is suggested that linker histone H1, while not required for mitotic chromatin condensation, plays important roles in nucleosome spacing and interphase chromatin compaction and acts as a global transcription regulator.
Journal ArticleDOI
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing.
TL;DR: Evidence is provided that distinctive sets of ERVs are silenced by Setdb1 in different types of somatic cells, suggesting a general function in ERV silencing.
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Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
Lance R. Thomas,Hiroki Miyashita,Robin Milley Cobb,Steven Pierce,Makoto Tachibana,Elias Hobeika,Michael Reth,Yoichi Shinkai,Eugene M. Oltz +8 more
TL;DR: Findings indicate that the H3K9me2 epigenetic mark affects a highly restricted set of processes during lymphocyte development and activation.