H
Hayato Nakagawa
Researcher at University of Tokyo
Publications - 177
Citations - 7031
Hayato Nakagawa is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 125 publications receiving 5679 citations. Previous affiliations of Hayato Nakagawa include University of California, San Diego & Memorial Hospital of South Bend.
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Journal ArticleDOI
Radiofrequency Ablation for Hepatocellular Carcinoma: 10-Year Outcome and Prognostic Factors
Shuichiro Shiina,Ryosuke Tateishi,Toru Arano,Koji Uchino,Kenichiro Enooku,Hayato Nakagawa,Yoshinari Asaoka,Takahisa Sato,Ryota Masuzaki,Yuji Kondo,Tadashi Goto,Haruhiko Yoshida,Masao Omata,Kazuhiko Koike +13 more
TL;DR: RFA could be locally curative for HCC, resulting in survival for as long as 10 years, and was a safe procedure, according to a collected database.
Journal ArticleDOI
Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma
Naoto Fujiwara,Hayato Nakagawa,Yotaro Kudo,Ryosuke Tateishi,Masataka Taguri,Takeyuki Watadani,Ryo Nakagomi,Mayuko Kondo,Takuma Nakatsuka,Tatsuya Minami,Masaya Sato,Koji Uchino,Kenichiro Enooku,Yuji Kondo,Yoshinari Asaoka,Yasuo Tanaka,Kuni Ohtomo,Shuichiro Shiina,Kazuhiko Koike +18 more
TL;DR: Body composition rather than BMI is a major determinant of prognosis in patients with HCC, and sarcopenia, IMF deposition, and visceral adiposity independently predict mortality in patientsWith HCC.
Journal ArticleDOI
Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling
Guobin He,Debanjan Dhar,Hayato Nakagawa,Hayato Nakagawa,Joan Font-Burgada,Hisanobu Ogata,Hisanobu Ogata,Yuhong Jiang,Shabnam Shalapour,Ekihiro Seki,Shawn Yost,Kristen Jepsen,Kelly A. Frazer,Olivier Harismendy,Maria Hatziapostolou,Dimitrios Iliopoulos,Atsushi Suetsugu,Robert M. Hoffman,Ryosuke Tateishi,Kazuhiko Koike,Michael Karin +20 more
TL;DR: In this article, the authors describe isolation and characterization of HCC progenitor cells (HcPCs) from different mouse HCC models and show that cells resembling HcPC cells reside within dysplastic lesions that appear several months before HCC nodules.
Journal ArticleDOI
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development
Hayato Nakagawa,Atsushi Umemura,Koji Taniguchi,Joan Font-Burgada,Debanjan Dhar,Hisanobu Ogata,Zhenyu Zhong,Mark A. Valasek,Ekihiro Seki,Juan Hidalgo,Kazuhiko Koike,Randal J. Kaufman,Michael Karin +12 more
TL;DR: Both NASH and HCC development were dependent on TNF produced by inflammatory macrophages that accumulate in the MUP-uPA liver in response to hepatocyte ER stress.
Journal ArticleDOI
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.
Joan Font-Burgada,Shabnam Shalapour,Suvasini Ramaswamy,Brian Hsueh,David Rossell,Atsushi Umemura,Koji Taniguchi,Hayato Nakagawa,Mark A. Valasek,Li Ye,Janel L. Kopp,Maike Sander,Hannah Carter,Karl Deisseroth,Inder M. Verma,Michael Karin +15 more
TL;DR: A pre-existing population of periportal hepatocytes, located in the portal triads of healthy livers and expressing low amounts of Sox9 and other bile-duct-enriched genes, undergo extensive proliferation and replenish liver mass after chronic hepatocyte-depleting injuries and represent a unique way to restore tissue function and avoid tumorigenesis.