T
Tsuneo Ikenoue
Researcher at University of Tokyo
Publications - 93
Citations - 4998
Tsuneo Ikenoue is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 37, co-authored 93 publications receiving 4562 citations. Previous affiliations of Tsuneo Ikenoue include Institute of Medical Science.
Papers
More filters
Journal ArticleDOI
Functional analysis of PIK3CA gene mutations in human colorectal cancer.
Tsuneo Ikenoue,Fumihiko Kanai,Yohko Hikiba,Toshiyuki Obata,Yasuo Tanaka,Jun Imamura,Miki Ohta,Amarsanaa Jazag,Bayasi Guleng,Keisuke Tateishi,Yoshinari Asaoka,Masayuki Matsumura,Takao Kawabe,Masao Omata +13 more
TL;DR: Results show that almost all the colon cancer-associated PIK3CA mutations are functionally active so that they are likely to be involved in carcinogenesis.
Journal ArticleDOI
Correction: Corrigendum: A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion
Tsuneo Ikenoue,Yumi Terakado,Hayato Nakagawa,Yohko Hikiba,Tomoaki Fujii,Daisuke Matsubara,Rei Noguchi,Chi Zhu,Keisuke Yamamoto,Yotaro Kudo,Yoshinari Asaoka,Kiyoshi Yamaguchi,Hideaki Ijichi,Keisuke Tateishi,Noriyoshi Fukushima,Shin Maeda,Kazuhiko Koike,Yoichi Furukawa +17 more
TL;DR: Generation of the mice with liver-specific KrasG12D expression and Pten deletion and strategy to generate the compound mice are presented.
Journal ArticleDOI
Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan
Shin Maeda,Keiji Ogura,Hideo Yoshida,Fumihiko Kanai,Tsuneo Ikenoue,Naoya Kato,Yasushi Shiratori,Masao Omata +7 more
TL;DR: Most H pylori isolates in Japan are positive for vacuolating cytotoxin and CagA, and thus these virulence factors cannot be used as markers to discern the risk of developing serious gastroduodenal pathologies in the hosts.
Journal ArticleDOI
Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors.
Hirotsugu Watabe,Yutaka Yamaji,Makoto Okamoto,Shintaro Kondo,Miki Ohta,Tsuneo Ikenoue,Jun Kato,Goichi Togo,Masayuki Matsumura,Haruhiko Yoshida,Takao Kawabe,Masao Omata +11 more
TL;DR: Hypertension is a significant risk factor for delayed colorectal postpolypectomy hemorrhage and the interval between polypectomy and hemorrhage can be as long as 14 days in the presence of hypertension.
Journal ArticleDOI
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
Hideaki Ijichi,Anna Chytil,Agnieszka E. Gorska,Mary Aakre,Brian Bierie,Motohisa Tada,Dai Mohri,Koji Miyabayashi,Yoshinari Asaoka,Shin Maeda,Tsuneo Ikenoue,Keisuke Tateishi,Christopher V.E. Wright,Kazuhiko Koike,Masao Omata,Harold L. Moses +15 more
TL;DR: The data indicate that tumor-stromal interactions via a Cxcr2-dependent chemokine and Ctgf axis can regulate PDAC progression and suggest that inhibiting tumor-stromal interactions might be a promising therapeutic strategy for PDAC.