Yong Li

TL;DR: It is reported that NEST, the recombinant esterase domain of NTE, can catalyze hydrolysis of several naturally occurring membrane-associated lipids, and the possibility that NTE and its homologues may be involved in intracellular membrane trafficking is raised.

TL;DR: The N-terminal amino acid sequences of proteolytic fragments of neuropathy target esterase (NTE), covalently labelled on its active-site serine by a biotinylated organophosphorus ester, were determined and used to deduce the location of this serine residue and to initiate cloning of its cDNA.

TL;DR: Histological analysis indicated that NTE is essential for the formation of the labyrinth layer and survival and differentiation of secondary giant cells in adults and fetal mice, and impairment of vasculogenesis in the yolk sacs and embryos of null mutant conceptuses suggested that N TE is also required for normal blood vessel development.

TL;DR: The data suggest that NTE is anchored in the ER via its TM, that its R- and C-Domains also interact with the cytoplasmic face of the ER, and that overexpression of NTE causes ER aggregation via intermolecular association of its C-domains.

TL;DR: Distal degeneration of the longest spinal axons is described in ∼3-week-old nestin-cre:NTEfl/fl mice and in adult C57BL/6J mice after acute dosing with a neuropathic organophosphate: in both groups early degenerative lesions were followed by swellings comprising accumulated axoplasmic material.