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Yong Xu
Researcher at Nanjing Forestry University
Publications - 1637
Citations - 54071
Yong Xu is an academic researcher from Nanjing Forestry University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 88, co-authored 1391 publications receiving 39268 citations. Previous affiliations of Yong Xu include Peking University & Northwestern Polytechnical University.
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Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790→ methionine790 mutant
Shilin Xu,Shilin Xu,Lianwen Zhang,Lianwen Zhang,Chang Shaohua,Chang Shaohua,Jinfeng Luo,Xiaoyun Lu,Zhengchao Tu,Yingxue Liu,Zhang Zhang,Yong Xu,Xiaomei Ren,Ke Ding +13 more
TL;DR: A series of 5,8-dioxo-pyrimido[4,5-e][1,4]diazepine derivatives were designed and synthesized as new inhibitors against wild-type EGFR and a panel of mutants, including the clinical resistance related T790M mutants.
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Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer
Xiaoqian Xue,Yan Zhang,Chao Wang,Zhang Maofeng,Qiuping Xiang,Junjian Wang,Anhui Wang,Chenchang Li,Cheng Zhang,Lingjiao Zou,Rui Wang,Shuang Wu,Yong-Zhi Lu,Hongwu Chen,Ke Ding,Guohui Li,Yong Xu +16 more
TL;DR: Compound (R)-12 is a promising lead compound for the development of a new class of therapeutics for the treatment of CRPC, and demonstrates reasonable anti-proliferation and colony formation inhibition effect in prostate cancer cell lines such as 22Rv1 and C4-2B.
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Delignification of poplar for xylo-oligosaccharides production using lactic acid catalysis.
TL;DR: In this article, the effect of delignification on xylo-oligosaccharides (XOS) production from lignocelluloses by organic acid catalysis was investigated.
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A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking
TL;DR: Evaluations showed that the combined strategy consistently outperformed the sole use of docking-based and pharmacophore-based methods and was a possible way for improving the accuracy of in silico target prediction and a method for target ranking.
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Evaluating health-related quality of life impact of chronic conditions among older adults from a rural town in Suzhou, China.
Chen-Wei Pan,Xiao-Ling Cong,Hui-Jun Zhou,Xingzhi Wang,Hong-Peng Sun,Yong Xu,Pei Wang,Pei Wang +7 more
TL;DR: Depression, stroke, heart disease and cognitive dysfunction had significantly adverse impact on the EQ-5D index score, and chronic conditions were found to contribute to HRQOL loss in older Chinese population.