Y
Yongjie Yang
Researcher at Johns Hopkins University
Publications - 5
Citations - 597
Yongjie Yang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Excitotoxicity & Nervous system. The author has an hindex of 5, co-authored 5 publications receiving 548 citations.
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Journal ArticleDOI
Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1.
Yongjie Yang,Oguz Gozen,Andrew M. Watkins,Ileana Lorenzini,Angelo C. Lepore,Yuanzheng Gao,Svetlana Vidensky,Jean Brennan,David J. Poulsen,Jeong Won Park,Noo Li Jeon,Michael B. Robinson,Jeffrey D. Rothstein +12 more
TL;DR: It is shown that presynaptic terminals regulate astroglial synaptic functions, GLT1/EAAT2, via kappa B-motif binding phosphoprotein (KBBP), the mouse homolog of human heterogeneous nuclear ribonucleoprotein K (hnRNP K), which binds the GLT 1/EAat2 promoter.
Journal ArticleDOI
Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice
Yongjie Yang,Svetlana Vidensky,Lin Jin,Chunfa Jie,Ileana Lorenzini,Miriam Frankl,Jeffrey D. Rothstein +6 more
TL;DR: These studies support ALDH1L1 as a general CNS astroglial marker and investigated astrocyte heterogeneity in the CNS by comparing the molecular identity of the ALDH 1L1+ and GLT1+ astroCytes from astrogLial reporter mice.
Journal ArticleDOI
Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.
TL;DR: Investigating the role of DNA methylation in physiological and pathological EAAT2/GLT1 expression found hypermethylation on selective CpG sites of the GLT1 promoter is involved in repression of GLT 1 promoter activation, but this regulation does not play a role in astroglial dysfunction ofEAAT2 expression in patients with ALS.
Journal ArticleDOI
Nuclear Factor-κB Contributes to Neuron-Dependent Induction of Glutamate Transporter-1 Expression in Astrocytes
TL;DR: It is suggested that nuclear factor-κB contributes to neuron-dependent regulation of astrocytic GLT-1 transcription and chromatin immunoprecipitation showed that p65 and p50 interact with these sites in adult cortex, but not in kidney (a tissue that expresses no detectable GLT1).
Book ChapterDOI
Specialized Neurotransmitter Transporters in Astrocytes
TL;DR: Transporters are vital for the normal CNS physiology by maintaining neurotransmitter homeostasis, modulating synaptic transmission and preventing neurological damage induced by the imbalance of neurotransmitters.