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Yosef Shiloh

Researcher at Tel Aviv University

Publications -  206
Citations -  35738

Yosef Shiloh is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Ataxia-telangiectasia & DNA damage. The author has an hindex of 75, co-authored 200 publications receiving 34100 citations. Previous affiliations of Yosef Shiloh include German Cancer Research Center & Weizmann Institute of Science.

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Journal Article

Rapamycin resistance in ataxia-telangiectasia.

Heather Beamish, +7 more
- 05 Sep 1996 - 
TL;DR: 3 A-T cell lines are more resistant than control cells to rapamycin's growth inhibiting effects but were more sensitive to the PI3-kinase inhibitor wortmannin, demonstrating that the ATM protein is not a direct target for rapamyzin but its functional loss renders cells more resistant to this compound.
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Novel DNA sequences at chromosome 10q26 are amplified in human gastric carcinoma cell lines: molecular cloning by competitive DNA reassociation

Orna Mor, +9 more
- 11 Jan 1991 - 
TL;DR: The cloned sequences supply a starting point for identification of novel genes which might be involved in the pathogenesis of gastric cancers, and are located in a relatively unexplored domain of the human genome.
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In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia.

Yosef Shiloh, +2 more
- 01 Aug 2004 - 
TL;DR: A high throughput strategy for drug screening for A-T that is based on a certain redundancy among ATM and related proteins gives hope that activation of ATM-redundant activities might form a basis for drug treatment of A- T.
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Astrocyte Dysfunction Associated with Cerebellar Attrition in a Nijmegen Breakage Syndrome Animal Model

Ronit Galron, +10 more
- 29 Jan 2011 - 
TL;DR: It is shown that conditional inactivation of the murine Nbs1 gene has a profound effect on the integrity and the functionality of the glial cells, which suggests their crucial role in the pathogenesis of NBS.
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Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain

Michal Kirshner, +7 more
- 01 Mar 2012 - 
TL;DR: The results indicate that malfunctioning DNA damage response severely affects the integrity of the nigro-striatal pathway and suggest a new neurodegenerative pathway in Parkinsonian syndromes.