Yosef Shiloh

TL;DR: This connection between genome instability-oxidative stress connection and ATM deficiency may provide new insights into the phenotypes associated with genetic deficiencies of DNA damage responses, and point to new strategies to alleviate some of their clinical symptoms.

TL;DR: In this paper, the authors show that DNA double-strand break (DSBs) induce monoubiquitylation of histone H2B, a modification that is associated in undamaged cells with transcription elongation.

TL;DR: Expander 2.0 as mentioned in this paper is an integrative package for the analysis of gene expression data, designed as a 'one-stop shop' tool that implements various data analysis algorithms ranging from the initial steps of normalization and filtering, through clustering and biclustering, to high-level functional enrichment analysis that points to biological processes that are active in the examined conditions, and to promoter cis-regulatory elements analysis that elucidates transcription factors that control the observed transcriptional response.

TL;DR: It is shown that ATM is a key regulator of multiple signaling cascades which respond to DNA strand breaks induced by damaging agents or by normal processes, such as meiotic or V(D)J recombination, which involve the activation of cell cycle checkpoints, DNA repair and apoptosis.

TL;DR: Using human genomic sequences, models for binding sites of known transcription factors, and gene expression data, it is demonstrated that the reverse engineering approach, which infers regulatory mechanisms from gene expression patterns, can reveal transcriptional networks in human cells.