Y
Yosef Shiloh
Researcher at Tel Aviv University
Publications - 206
Citations - 35738
Yosef Shiloh is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Ataxia-telangiectasia & DNA damage. The author has an hindex of 75, co-authored 200 publications receiving 34100 citations. Previous affiliations of Yosef Shiloh include German Cancer Research Center & Weizmann Institute of Science.
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Journal ArticleDOI
Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system.
Koby Baranes,Dorit Raz-Prag,Anat Nitzan,Anat Nitzan,Ronit Galron,Ruth Ashery-Padan,Ygal Rotenstreich,Yaniv Assaf,Yosef Shiloh,Zhao-Qi Wang,Ari Barzilai,Arieh S. Solomon +11 more
TL;DR: It is reported that conditional targeted disruption of the murine NBS1 gene in the CNS results in mal-development, degeneration, disorganization and dysfunction of the Murine visual system, especially in the optic nerve.
Journal ArticleDOI
Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia.
TL;DR: The indication that ubiquitin conjugate levels and ubiquit in conjugation capabilities are enhanced upon oxidative stress without significant changes in GSSG/GSH ratios indicates that assays of ubiquitination provide a sensitive measure of cellular stress.
Journal ArticleDOI
The ATM protein: The importance of being active
Yosef Shiloh,Yael Ziv +1 more
TL;DR: Two papers in this issue strikingly show that, in mice, the presence of a catalytically inactive version of ATM is embryonically lethal, which is surprising because mice completely lacking ATM have a much more moderate phenotype.
Journal ArticleDOI
The EXPANDER Integrated Platform for Transcriptome Analysis.
Tom Aharon Hait,Adi Maron-Katz,Dorit Sagir,David Amar,Igor Ulitsky,Chaim Linhart,Amos Tanay,Roded Sharan,Yosef Shiloh,Ran Elkon,Ron Shamir +10 more
TL;DR: Support for combined analysis of gene expression and ChIP-seq data to enhance the inference of transcriptional networks and their functional interpretation is added in the recent version of EXPANDER.
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Phosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress
Sapir Schlam-Babayov,Ariel Bensimon,Michal Harel,Tamar Geiger,Ruedi Aebersold,Ruedi Aebersold,Yael Ziv,Yosef Shiloh +7 more
TL;DR: A comprehensive phosphoproteomic analysis in human wild‐type and A‐T cells treated with the double‐strand break‐inducing chemical, neocarzinostatin, uncovered fine‐tuned dynamics between the PIKKs following genotoxic stress, such as DNA‐PK‐dependent attenuation of ATM.