Y
Yosef Shiloh
Researcher at Tel Aviv University
Publications - 206
Citations - 35738
Yosef Shiloh is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Ataxia-telangiectasia & DNA damage. The author has an hindex of 75, co-authored 200 publications receiving 34100 citations. Previous affiliations of Yosef Shiloh include German Cancer Research Center & Weizmann Institute of Science.
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Journal Article
Simultaneous Identification and Quantification of Proteins by Differential 16O/18O Labeling and UPLC-MS/MS Applied to Mouse Cerebellar Phosphoproteome Following Irradiation
TL;DR: Differential proteolytic (18)O labeling was applied to relative quantification of protein phosphorylation in mouse brain following treatment with ionizing radiation, showing the activation of kinase-regulated signaling cascades by irradiation.
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Genome instability: Linking ageing and brain degeneration.
TL;DR: This review discusses similarities and differences between ageing-associated decline of brain functionality and the detrimental effect of genome instability and highlights cell classes whose role in these processes might have been underestimated-glia and microglia.
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A YAC Contig Spanning the Ataxia-Telangiectasia Locus (Groups A and C) at 11q22-q23
Galit Rotman,Kinneret Savitsky,Yael Ziv,Charlotte G. Cole,Michael J. Higgins,Irit Bar-Am,Ian Dunham,Anat Bar-Shira,Lina Vanagaite,Shizhen Qin,Jialu Zhang,Norma J. Nowak,Settara C. Chandrasekharappa,Hans Lehrach,Lydia Avivi,Thomas B. Shows,Francis S. Collins,David R. Bentley,Yosef Shiloh +18 more
TL;DR: A YAC contig spanning 4.5 Mb, which includes the D11S1817-D11S927 interval, was constructed using two whole genome libraries (ICRF and St. Louis), and a chromosome 11-specific library, and was expedited by prior generation of a region-specific ICRF sublibrary using Alu-PCR products derived from a radiation hybrid.
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Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype
TL;DR: The presence of AtmKD is indeed more harmful to D SB repair than Atm loss, but the murine central nervous system can reasonably tolerate the extent of this DSB repair impairment.
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The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies.
N. G. Antoniou,Nefeli Lagopati,Dimitrios Ilias Balourdas,Michail Nikolaou,Alexandros Papalampros,Panagiotis Vasileiou,Vassilios Myrianthopoulos,Athanassios Kotsinas,Yosef Shiloh,Michalis Liontos,Vassilis G. Gorgoulis,Vassilis G. Gorgoulis,Vassilis G. Gorgoulis +12 more
TL;DR: Insight is provided into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.