Takashi Masuko

TL;DR: It is shown that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular level of reduced glutathione (GSH).

TL;DR: It is shown that orthotopic transplantation of a CD44 variant isoform-expressing (CD44v(+)) subpopulation of 4T1 breast cancer cells, but not that of aCD 44v(-) subpopulation, in mice results in efficient lung metastasis accompanied by expansion of stem-like cancer cells.

TL;DR: It is shown that head and neck squamous cell carcinoma cells that express variant isoforms of CD44 (CD44v) rely on the activity of the cystine transporter subunit xCT for control of their redox status, and xCT inhibition selectively induces apoptosis in CD44v-expressing tumor cells without affecting CD 44v-negative differentiated cells in the same tumor.

TL;DR: The SCE frequency increase in BLM −/− cells was considerably reduced and the enhanced targeted integration observed in BLM−/− Cells was almost completely abolished, indicating that a large portion of the SCE in BLM+/+ cells occurs via homologous recombination, and homologously recombination events increase with the defect of BLM function.

TL;DR: In this article, a gastric gland residing at the squamo-columnar junction (SCJ) in normal mouse stomach contains CD44(+) stem cell-like slow-cycling cells and this characteristic CD44+ gland was expanded by prostaglandin E2 (PGE(2)) and Wnt signaling in K19-Wnt1/C2mE mouse, a genetic mouse model for gastric tumorigenesis.