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Yoshihiro Ishibashi
Researcher at Takeda Pharmaceutical Company
Publications - 38
Citations - 3365
Yoshihiro Ishibashi is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Peptide sequence & Peptide. The author has an hindex of 21, co-authored 38 publications receiving 3183 citations.
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Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
Journal ArticleDOI
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
Tetsuya Ohtaki,Satoshi Kumano,Yoshihiro Ishibashi,Kazuhiro Ogi,Hideki Matsui,Mioko Harada,Chieko Kitada,Tsutomu Kurokawa,Haruo Onda,Masahiko Fujino +9 more
TL;DR: Porcine GALP is therefore an endogenous ligand that preferentially binds the GALR2 receptor, whereas galanin is relatively non-selective.
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Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors
Yasushi Masuda,Yoshihiro Takatsu,Yasuko Terao,Satoshi Kumano,Yoshihiro Ishibashi,Masato Suenaga,Michiko Abe,Shoji Fukusumi,Takuya Watanabe,Yasushi Shintani,Takao Yamada,Shuji Hinuma,Nobuhiro Inatomi,Tetsuya Ohtaki,Haruo Onda,Masahiko Fujino +15 more
TL;DR: The identification of the receptors for EG-VEGF/prokineticins may provide a novel molecular basis for the regulation of angiogenesis in endocrine glands.
Journal ArticleDOI
Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens.
TL;DR: It is concluded that racemization, isomerization, and oxidation of alpha B-crystallin occur spontaneously in the aging process.
Journal ArticleDOI
Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.
Yukio Shimomura,Masaaki Mori,Tsukasa Sugo,Yoshihiro Ishibashi,Michiko Abe,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Yasuhiro Sumino,Masahiko Fujino +9 more
TL;DR: Melanin-concentrating hormone, which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor and demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human S LC-1-expressing CHO cells.