Y
Yoshiko Takeda-Uchimura
Researcher at Nagoya University
Publications - 12
Citations - 1394
Yoshiko Takeda-Uchimura is an academic researcher from Nagoya University. The author has contributed to research in topics: Keratan sulfate & Sulfation. The author has an hindex of 9, co-authored 9 publications receiving 1278 citations. Previous affiliations of Yoshiko Takeda-Uchimura include Stanford University.
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Journal ArticleDOI
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Sandip Ray,Markus Britschgi,Charles Herbert,Yoshiko Takeda-Uchimura,Adam L. Boxer,Kaj Blennow,Leah Friedman,Douglas Galasko,Marek Jutel,Anna Karydas,Jeffrey Kaye,Jerzy Leszek,Bruce L. Miller,Lennart Minthon,Joseph F. Quinn,Gil D. Rabinovici,William H. Robinson,Marwan N. Sabbagh,Yuen T. So,D. Larry Sparks,Massimo Tabaton,Jared R. Tinklenberg,Jerome A. Yesavage,Robert Tibshirani,Tony Wyss-Coray,Tony Wyss-Coray +25 more
TL;DR: Biological analysis of the 18 proteins found in blood plasma points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
Journal ArticleDOI
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
Markus Britschgi,C. E. Olin,Hudson Johns,Yoshiko Takeda-Uchimura,Melburne C. Lemieux,Kaspar Rufibach,Jayakumar Rajadas,Hua Zhang,Beren H. Tomooka,William H. Robinson,William H. Robinson,C. Clark,Anne M. Fagan,Douglas Galasko,David M. Holtzman,Marek Jutel,J. A. Kaye,Cynthia A. Lemere,Jerzy Leszek,Guangpu Li,Elaine R. Peskind,Joseph F. Quinn,Jerome A. Yesavage,Jerome A. Yesavage,Jorge Ghiso,Tony Wyss-Coray,Tony Wyss-Coray +26 more
TL;DR: The findings support the concept of conformation-specific, cross-reactive antibodies that may protect against amyloidogenic toxic peptides and stimulating the production of such neuroprotective antibodies or passively administering them to the elderly population may provide a preventive measure toward AD.
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Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
Zui Zhang,Yoshiko Takeda-Uchimura,Tahmina Foyez,Shiori Ohtake-Niimi,Narentuya,Hiroyasu Akatsu,Kazuchika Nishitsuji,Makoto Michikawa,Tony Wyss-Coray,Kenji Kadomatsu,Kenji Uchimura +10 more
TL;DR: Keratan sulfate modified with sialic acids having a molecular mass of 125–220 kDa and the carbohydrate sulfotransferase GlcNAc6ST1 were up-regulated in the brains of two transgenic mouse models and the heads of patients with AD.
Journal ArticleDOI
Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.
Markus Britschgi,Yoshiko Takeda-Uchimura,Edward Rockenstein,Hudson Johns,Eliezer Masliah,Tony Wyss-Coray,Tony Wyss-Coray +6 more
TL;DR: The authors' data in two independent mouse models with genetic changes in key regulators of the complement system support the hypothesis that the terminal pathway has an active role in the development of tau pathology.
Journal ArticleDOI
Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis.
Tahmina Foyez,Yoshiko Takeda-Uchimura,Shinsuke Ishigaki,Narentuya,Zui Zhang,Gen Sobue,Kenji Kadomatsu,Kenji Uchimura +7 more
TL;DR: Results indicate that both galactose-6- and N acteylglucosamine- 6-sulfated KS elicited in the spinal cord and brainstem are associated with the degeneration of spinal and bulbar lower motor neurons in ALS pathology and may play a role in disease progression via microglial activation and proliferation.