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Yosuke Nakatani
Researcher at Eisai
Publications - 7
Citations - 112
Yosuke Nakatani is an academic researcher from Eisai. The author has contributed to research in topics: AMPA receptor & Cmax. The author has an hindex of 5, co-authored 7 publications receiving 94 citations. Previous affiliations of Yosuke Nakatani include National Institute of Radiological Sciences & Tohoku University.
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Journal ArticleDOI
Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor.
Norihito Oi,Norihito Oi,Norihito Oi,Michiyuki Suzuki,Michiyuki Suzuki,Taro Terauchi,Masaki Tokunaga,Yosuke Nakatani,Yosuke Nakatani,Yosuke Nakatani,Noboru Yamamoto,Toshimitsu Fukumura,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Makoto Higuchi,Makoto Higuchi +16 more
TL;DR: The design, synthesis, and evaluation of OXR ligands related to (1R,2S)-2-(((2-methyl-4-methoxymethylpyrimidin-5-yl)oxy)methyl)-N-(5-fluoropyridIn-2-yl)-2-(3- fluorophenyl)cyclopropanecarboxamide) applicable to positron emission tomography (PET) imaging are described.
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Utility of Cerebrospinal Fluid Drug Concentration as a Surrogate for Unbound Brain Concentration in Nonhuman Primates
Yoko Nagaya,Yoshitane Nozaki,Kazumasa Kobayashi,Osamu Takenaka,Yosuke Nakatani,Kazutomi Kusano,Tsutomu Yoshimura,Hiroyuki Kusuhara +7 more
TL;DR: C(CSF) could be used as a surrogate for C(ISF) in nonhuman primates when drugs undergo active efflux by transporters at the blood-brain barrier.
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E2012, a novel gamma-secretase modulator, decreases plasma amyloid-beta (Aβ) levels in humans
TL;DR: Results from rat studies with E2012 were predictive of the results obtained in humans for plasma Aβ effect over 24 hr, supporting the use of CSF as a surrogate matrix for effects on brain Aβ in humans.
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Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors.
Norihito Oi,Norihito Oi,Masaki Tokunaga,Michiyuki Suzuki,Michiyuki Suzuki,Yuji Nagai,Yosuke Nakatani,Yosuke Nakatani,Noboru Yamamoto,Jun Maeda,Takafumi Minamimoto,Ming-Rong Zhang,Tetsuya Suhara,Makoto Higuchi +13 more
TL;DR: The current approach has facilitated the discovery of a PET probe potentially suitable for translational research and development focused on AMPA receptors that was shown by autoradiography to specifically bind to the neocortex and hippocampus, consistent with AMPA receptor localization.
Journal ArticleDOI
A Small-Animal Pharmacokinetic/Pharmacodynamic PET Study of Central Serotonin 1A Receptor Occupancy by a Potential Therapeutic Agent for Overactive Bladder
Yosuke Nakatani,Yosuke Nakatani,Yosuke Nakatani,Michiyuki Suzuki,Michiyuki Suzuki,Masaki Tokunaga,Jun Maeda,Miyuki Sakai,Hiroki Ishihara,Takashi Yoshinaga,Osamu Takenaka,Ming-Rong Zhang,Ming-Rong Zhang,Tetsuya Suhara,Tetsuya Suhara,Makoto Higuchi,Makoto Higuchi +16 more
TL;DR: The utility of PET RO and plasma pharmacokinetic assays with the aid of adequate mathematical models in determining the in vivo characteristics of a drug acting on 5-HT1A receptors and thereby counteracting OAB is supported.