T
Takafumi Minamimoto
Researcher at National Institute of Radiological Sciences
Publications - 84
Citations - 1543
Takafumi Minamimoto is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 20, co-authored 69 publications receiving 1028 citations. Previous affiliations of Takafumi Minamimoto include National Presto Industries & Kyoto Prefectural University of Medicine.
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Journal ArticleDOI
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Yuji Nagai,Naohisa Miyakawa,Hiroyuki Takuwa,Yukiko Hori,Kei Oyama,Bin Ji,Manami Takahashi,Xi Ping Huang,Samuel T. Slocum,Jeffrey F. DiBerto,Yan Xiong,Takuya Urushihata,Toshiyuki Hirabayashi,Atsushi Fujimoto,Koki Mimura,Justin G. English,Jing Liu,Ken-ichi Inoue,Ken-ichi Inoue,Katsushi Kumata,Chie Seki,Maiko Ono,Masafumi Shimojo,Ming-Rong Zhang,Yutaka Tomita,Jin Nakahara,Tetsuya Suhara,Masahiko Takada,Makoto Higuchi,Jian Jin,Bryan L. Roth,Takafumi Minamimoto +31 more
TL;DR: DCZ represents a potent, selective, metabolically stable and fast-acting DREADD agonist with utility in both mice and nonhuman primates for a variety of applications.
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Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value
Mark A.G. Eldridge,Walter Lerchner,Richard C. Saunders,Hiroyuki Kaneko,Kristopher W. Krausz,Frank J. Gonzalez,Bin Ji,Makoto Higuchi,Takafumi Minamimoto,Barry J. Richmond +9 more
TL;DR: Results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC, which is related to the judgment of reward size.
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PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.
Yuji Nagai,Erika Kikuchi,Walter Lerchner,Ken-ichi Inoue,Bin Ji,Mark A.G. Eldridge,Hiroyuki Kaneko,Yasuyuki Kimura,Arata Oh-Nishi,Yukiko Hori,Yoko Kato,Toshiyuki Hirabayashi,Atsushi Fujimoto,Katsushi Kumata,Ming-Rong Zhang,Ichio Aoki,Tetsuya Suhara,Makoto Higuchi,Masahiko Takada,Barry J. Richmond,Takafumi Minamimoto +20 more
TL;DR: It is demonstrated that inactivating bilateral rmCD through activation of hM4Di produces a significant and reproducible loss of sensitivity to reward value in monkeys, indicating that the rmCD is involved in making normal judgments about the value of reward.
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Measuring and modeling the interaction among reward size, delay to reward, and satiation level on motivation in monkeys.
TL;DR: The results provide a quantitative account of the interaction of external and internal factors on instrumental behavior, and allow the concept of subjective value of a rewarding outcome to be extended to account also for slow changes in the internal drive of the subject.
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Neuronal encoding of reward value and direction of actions in the primate putamen.
TL;DR: The results support the view that putamen neurons encode reward value and direction of actions, which may be a basis for mediating the processes leading from reward-value mapping to guiding ongoing actions toward their expected outcomes and directions.