Y
Youngjeon Lee
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 83
Citations - 1325
Youngjeon Lee is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Melatonin & Medicine. The author has an hindex of 17, co-authored 74 publications receiving 984 citations. Previous affiliations of Youngjeon Lee include Korea University of Science and Technology & Daegu Gyeongbuk Institute of Science and Technology.
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Journal ArticleDOI
Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells.
Yunkyung Hong,Jinyoung Won,Youngjeon Lee,Youngjeon Lee,Seunghoon Lee,Kanghui Park,Kyu-Tae Chang,Yonggeun Hong +7 more
TL;DR: It is suggested that melatonin is a potential chemotherapeutic agent for treatment of colon cancer, the effects of which are mediated by regulation of both cell death and senescence in cancerous cells with minimized cardiotoxicity.
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Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke
TL;DR: The role of microglial mediators in acute ischemic stroke is discussed and preclinical and clinical studies focused on microglia in stroke models are elaborate to implement therapeutic strategies using immunomodulatory interventions in isChemic stroke.
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Induction of Autophagy Promotes Preattachment Development of Bovine Embryos by Reducing Endoplasmic Reticulum Stress
Bong-Seok Song,Seung-Bin Yoon,Seung-Bin Yoon,Ji-Su Kim,Bo-Woong Sim,Young-Hyun Kim,Young-Hyun Kim,Jae-Jin Cha,Seon-A Choi,Hyun-Ki Min,Youngjeon Lee,Jae-Won Huh,Sang-Rae Lee,Sang-Hyun Kim,Deog-Bon Koo,Young-Kug Choo,Hwan Mook Kim,Sun-Uk Kim,Sun-Uk Kim,Kyu-Tae Chang,Kyu-Tae Chang +20 more
TL;DR: It is shown that the developmental competence of in vitro-produced (IVP) bovine embryos was highly dependent on the autophagy/ER stress balance, and that early embryogenesis of IVP bovines depends on an appropriate balance between autophagic activity and ER stress.
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Developmental Competence of Bovine Early Embryos Depends on the Coupled Response Between Oxidative and Endoplasmic Reticulum Stress
Seung-Bin Yoon,Seung-Bin Yoon,Seon-A Choi,Bo Woong Sim,Ji-Su Kim,Seong-Eun Mun,Pil-Soo Jeong,Hae-Jun Yang,Youngjeon Lee,Young-Ho Park,Bong Seok Song,Young-Hyun Kim,Kang Jin Jeong,Jae-Won Huh,Jae-Won Huh,Sang-Rae Lee,Sang-Rae Lee,Sun-Uk Kim,Sun-Uk Kim,Kyu Tae Chang,Kyu Tae Chang +20 more
TL;DR: In vitro developmental competence of IVP bovine embryos was highly dependent on the coupled response between oxidative and ER stresses, and ROS and sXBP-1 transcript levels were markedly decreased by supplementation with TUDCA, suggesting a possible mechanism governing the mutual regulation between ROS and ER stress.
Journal ArticleDOI
Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking
Ekyune Kim,Youngjeon Lee,Youngjeon Lee,Hyun-ju Lee,Ji-Su Kim,Bong-Seok Song,Jae-Won Huh,Sang-Rae Lee,Sun-Uk Kim,Sang-Hyun Kim,Yonggeun Hong,Insop Shim,Kyu-Tae Chang +12 more
TL;DR: Results suggest that mouse Vps26b-VPS29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network (TGN).