Y
Yu Du
Researcher at Chinese Academy of Sciences
Publications - 20
Citations - 721
Yu Du is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 10, co-authored 20 publications receiving 513 citations. Previous affiliations of Yu Du include Nanyang Technological University.
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Journal ArticleDOI
Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts.
TL;DR: The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed, which undergo enantioselective reactions with α,β-unsaturated imines.
Journal ArticleDOI
N-heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals.
Yuexia Zhang,Yu Du,Zhijian Huang,Jianfeng Xu,Xingxing Wu,Yuhuang Wang,Ming Wang,Song Yang,Richard D. Webster,Yonggui Robin Chi,Yonggui Robin Chi +10 more
TL;DR: An N-heterocyclic carbene-catalyzed β-Hydroxylation of enals is developed, which allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
Journal ArticleDOI
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
Kaixi Zhang,Yu Du,Yu Du,Zhangyong Si,Yang Liu,Michelle E. Turvey,Cheerlavancha Raju,Damien Keogh,Lin Ruan,Subramanion L. Jothy,Sheethal Reghu,Kalisvar Marimuthu,Partha Pratim De,Oon Tek Ng,Oon Tek Ng,José R. Mediavilla,Barry N. Kreiswirth,Yonggui Robin Chi,Jinghua Ren,Kam Chiu Tam,Xue-Wei Liu,Hongwei Duan,Yabin Zhu,Yuguang Mu,Paula T. Hammond,Guillermo C. Bazan,Kevin Pethe,Mary B. Chan-Park +27 more
TL;DR: An enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms and displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope.
Journal ArticleDOI
Enantioselective intramolecular formal [2 + 4] annulation of acrylates and α,β-unsaturated imines catalyzed by amino acid derived phosphines.
TL;DR: The first chiral phosphine-catalyzed activation of acrylates for intramolecular formal [2 + 4] reactions with unsaturated imines is described, which afford N-heterocycles with exceptionally high diastereo- and enantioselectivities.
Journal ArticleDOI
N-heterocyclic carbene organocatalytic reductive β,β-coupling reactions of nitroalkenes via radical intermediates.
TL;DR: For the first time, the presence of radical anion intermediate in NHC organocatalysis is observed and clearly verified.