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Yu-Hwa Huang
Researcher at Brigham and Women's Hospital
Publications - 31
Citations - 1693
Yu-Hwa Huang is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Immune system & Cell adhesion molecule. The author has an hindex of 17, co-authored 30 publications receiving 1427 citations. Previous affiliations of Yu-Hwa Huang include University of Münster & University of Würzburg.
Papers
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Journal ArticleDOI
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Yu-Hwa Huang,Chen Zhu,Yasuyuki Kondo,Ana C. Anderson,Amit Gandhi,Andrew Russell,Stephanie K. Dougan,Britt-Sabina Petersen,Espen Melum,Thomas Pertel,Kiera L. Clayton,Monika Raab,Qiang Chen,Nicole Beauchemin,Paul J. Yazaki,Michal Pyzik,Mario A. Ostrowski,Jonathan N. Glickman,Christopher E. Rudd,Hidde L. Ploegh,Andre Franke,Gregory A. Petsko,Vijay K. Kuchroo,Richard S. Blumberg +23 more
TL;DR: In this article, the authors showed that CEACAM1 facilitates the maturation and cell surface expression of TIM-3 by forming a heterodimeric interaction in cis through the highly related membrane-distal N-terminal domains of each molecule.
Journal ArticleDOI
HLA-G expression defines a novel regulatory T cell subset present in human peripheral blood and sites of inflammation
Ute Feger,Eva Tolosa,Yu-Hwa Huang,Anne Waschbisch,Tilo Biedermann,Arthur Melms,Heinz Wiendl,Heinz Wiendl +7 more
TL;DR: The presence of HLA-G(pos) T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.
Journal ArticleDOI
Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells.
TL;DR: Pregnant state in MS patients is characterized by an increase in the percentage ofCD56bright NK cells and by enhanced Th2 type cytokine secretion and a potential role for CD56bright regulatory NK cells in the control of autoimmune inflammation during pregnancy in MS is suggested.
Journal ArticleDOI
CEACAM1 as a multi-purpose target for cancer immunotherapy.
TL;DR: This review outlines CEACAM1's role as a therapeutic target for cancer treatment in light of these properties and highlights its function in various immune compartments and cancer types, including in the context of metastatic disease.
Patent
Modulation of the immune response
TL;DR: In this paper, compositions and methods for the modulation of T-cell tolerance can be upregulated or downregulated by concurrent enhancement or inhibition of CEACAMl/TIM3 interactions.