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Amit Gandhi
Researcher at Brigham and Women's Hospital
Publications - 27
Citations - 1062
Amit Gandhi is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Immune system & Pyridoxal kinase. The author has an hindex of 13, co-authored 25 publications receiving 766 citations. Previous affiliations of Amit Gandhi include Harvard University & University of Massachusetts Lowell.
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Journal ArticleDOI
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Yu-Hwa Huang,Chen Zhu,Yasuyuki Kondo,Ana C. Anderson,Amit Gandhi,Andrew Russell,Stephanie K. Dougan,Britt-Sabina Petersen,Espen Melum,Thomas Pertel,Kiera L. Clayton,Monika Raab,Qiang Chen,Nicole Beauchemin,Paul J. Yazaki,Michal Pyzik,Mario A. Ostrowski,Jonathan N. Glickman,Christopher E. Rudd,Hidde L. Ploegh,Andre Franke,Gregory A. Petsko,Vijay K. Kuchroo,Richard S. Blumberg +23 more
TL;DR: In this article, the authors showed that CEACAM1 facilitates the maturation and cell surface expression of TIM-3 by forming a heterodimeric interaction in cis through the highly related membrane-distal N-terminal domains of each molecule.
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Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Michal Pyzik,Timo Rath,Timothy Kuo,Sanda Win,Kristi Baker,Jonathan J. Hubbard,Jonathan J. Hubbard,Rosa Grenha,Amit Gandhi,Thomas D Krämer,Adam R. Mezo,Zachary Taylor,Kevin Mcdonnell,Vicki L. Nienaber,Jan Terje Andersen,Atsushi Mizoguchi,Laurence J. Blumberg,Shalaka Purohit,Susan D. Jones,Gregory J. Christianson,Wayne I. Lencer,Wayne I. Lencer,Inger Sandlie,Neil Kaplowitz,Derry C. Roopenian,Richard S. Blumberg +25 more
TL;DR: It is demonstrated that mice with global or liver-specific FcRn deletion exhibit hypoalbuminemia, albumin loss into the bile, and increased albumin levels in the hepatocyte, and that the main function of hepatic F cRn is to direct albumin into the circulation, thereby also increasing hepatocyte sensitivity to toxicity.
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Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
Shankar S. Iyer,Thomas Gensollen,Amit Gandhi,Sungwhan F. Oh,Joana F. Neves,Frédéric Collin,Richard Lavin,Carme Serra,Jonathan N. Glickman,Punyanganie S. de Silva,R. Balfour Sartor,Gurdyal S. Besra,Russell Hauser,Anthony Maxwell,Amadeu Llebaria,Richard S. Blumberg +15 more
TL;DR: Environmental derived oxazoles are identified as triggers of CD1d-dependent intestinal inflammatory responses that occur via activation of the AhR in the intestinal epithelium.
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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses
Laurence J. Blumberg,J E Humphries,Susan D. Jones,L B Pearce,Robert George Edward Holgate,Arron Hearn,J. Cheung,Atiya Mahmood,B Del Tito,J S Graydon,L E Stolz,Alan J. Bitonti,S Purohit,D de Graaf,K Kacena,Jan Terje Andersen,Jan Terje Andersen,Gregory J. Christianson,Derry C. Roopenian,Jonathan J. Hubbard,Jonathan J. Hubbard,Amit Gandhi,K Lasseter,Michal Pyzik,Richard S. Blumberg +24 more
TL;DR: The role of FcRn in humans is expanded by showing that it controls not only IgG protection from catabolism but also inflammatory pathways associated with IgG ICs involved in a variety of autoimmune diseases.
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CEACAM1 structure and function in immunity and its therapeutic implications.
TL;DR: This review examines recent structural information derived from the characterization of CEACAM1 and focuses on interactions and heterophilic modes of binding especially to microbes and how this relates to CEACam1 function.